Editing Apocrine (section)

==Apocrine metaplasia==
[[File:Histopathology of apocrine metaplasia of breast, annotated.png|thumb|290px|[[Micrograph]] showing apocrine [[metaplasia]] of the breast with typical features,<ref>Image by Mikael Häggström, MD. Reference for findings: {{cite web|url=https://www.pathologyoutlines.com/topic/breastapocrinemetaplasia.html|title=Apocrine metaplasia|author=Carlos C. Diez Freire, M.D., Shahla Masood, M.D.|website=Pathology Outlines}} Last author update: 28 May 2020.</ref> including apical snouts with eosinophilic granules. [[H&E stain]].]]
'''Apocrine metaplasia''' is a reversible transformation ([[metaplasia]]) of cells to an apocrine [[phenotype]]. It is common in the breast in the context of [[fibrocystic breast changes|fibrocystic change]]. It is seen in women mostly over the age of 50 years. Metaplasia happens when there is an irritation to the breast (breast cyst). Apocrine-like cells form in a lining of developing microcysts, due to the pressure buildup within the lumen. The pressure build up is caused by secretions.<ref>Dr Ayush Goel and Radswiki et al. Apocrine metaplasia of the breast.http://radiopaedia.org/articles/apocrine-metaplasia-of-the-breast</ref> This type of metaplasia represents an exception to the common rule of metaplasia increasing the risk for developing cancer in that apocrine metaplasia doesn't increase the possibility of developing breast cancer.<ref>{{Cite journal |last1=Wells |first1=C A |last2=El-Ayat |first2=G A |date=December 2007 |title=Non-operative breast pathology: apocrine lesions |journal=Journal of Clinical Pathology |volume=60 |issue=12 |pages=1313–1320 |doi=10.1136/jcp.2006.040626 |issn=0021-9746 |pmc=2095572 |pmid=18042688}}</ref> Metaplastic apocrine cells belong to the category of [[oncocytes]], which are a group characterized by abundant [[acidophilic]], granular cytoplasm (from the Greek root onco-, which means mass, bulk).