Editing Bcl-2 (section)

== Isoforms ==

The two [[isoforms]] of Bcl-2, Isoform 1, and Isoform 2, exhibit a similar fold. However, results in the ability of these isoforms to bind to the [[Bcl-2-associated death promoter|BAD]] and [[Bcl-2 homologous antagonist killer|BAK]] proteins, as well as in the structural topology and [[electrostatic potential]] of the binding groove, suggest differences in antiapoptotic activity for the two [[Protein isoform|isoforms]].<ref name="Human Bcl2 1G5M">{{PDB|1G5M}}; {{cite journal | vauthors = Petros AM, Medek A, Nettesheim DG, Kim DH, Yoon HS, Swift K, Matayoshi ED, Oltersdorf T, Fesik SW | title = Solution structure of the antiapoptotic protein bcl-2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 6 | pages = 3012–3017 | date = March 2001 | pmid = 11248023 | pmc = 30598 | doi = 10.1073/pnas.041619798 | doi-access = free | bibcode = 2001PNAS...98.3012P }}</ref>