Editing Bookmarking (section)

==Bookmarking as selective maintenance of an open chromatin state==
The term bookmarking was originally coined to describe the non-compaction of some [[gene promoter]]s during [[mitosis]].<ref>{{Cite journal | pmid = 9619097| year = 1998| last1 = John| first1 = S| title = Bookmarking genes for activation in condensed mitotic chromosomes| journal = BioEssays| volume = 20| issue = 4| pages = 275–9| last2 = Workman| first2 = J. L.| doi = 10.1002/(SICI)1521-1878(199804)20:4<275::AID-BIES1>3.0.CO;2-P}}</ref> More recently genome accessibility during interphase and mitosis has been directly compared on a genome-wide scale.<ref>{{Cite journal | pmid = 25373146| pmc = 4315295| year = 2015| last1 = Hsiung| first1 = C. C.| title = Genome accessibility is widely preserved and locally modulated during mitosis| journal = Genome Research| volume = 25| issue = 2| pages = 213–25| last2 = Morrissey| first2 = C. S.| last3 = Udugama| first3 = M| last4 = Frank| first4 = C. L.| last5 = Keller| first5 = C. A.| last6 = Baek| first6 = S| last7 = Giardine| first7 = B| last8 = Crawford| first8 = G. E.| last9 = Sung| first9 = M. H.| last10 = Hardison| first10 = R. C.| last11 = Blobel| first11 = G. A.| doi = 10.1101/gr.180646.114}}</ref> While gene promoters tend to be better preserved than distal regulatory elements, substantial variation exists at individual sites.