Editing Buspirone (section)

==Medical uses==
===Anxiety===
Buspirone is used for the short-term and long-term treatment of [[anxiety disorder]]s or symptoms of anxiety.<ref name=DM>{{cite web|title=Buspirone HCL (buspirone hydrochloride) tablet [Watson Laboratories, Inc.]|work=DailyMed|publisher=Watson Laboratories, Inc.|date=July 2013|access-date=14 November 2013|url=http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a3fe0ccd-565f-4d0a-a7ba-2fad7a819358}}</ref><ref name=TGA>{{cite web|title=Buspar (buspirone hydrochloride) Tablets 5 mg & 10 mg PRODUCT INFORMATION|work=TGA eBusiness Services|publisher=Aspen Pharma Pty Ltd|date=January 2010|access-date=14 November 2013|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-03962-3|format=PDF}}</ref><ref name=AMH>{{cite book | title=Australian Medicines Handbook | year=2013 | publisher=The Australian Medicines Handbook Unit Trust | isbn=978-0-9805790-9-3 | edition=2013 | place=Adelaide | veditors=Rossi S }}</ref><ref name=EMC>{{cite web |title=Buspirone 10mg Tablets |work=electronic Medicines Compendium |publisher=Actavis UK Ltd |date=10 September 2012 |access-date=14 November 2013 |url=http://www.medicines.org.uk/emc/medicine/23859/SPC/Buspirone+10mg+Tablets/|archive-date=13 November 2013|archive-url=https://web.archive.org/web/20131113191142/http://www.medicines.org.uk/emc/medicine/23859/SPC/Buspirone+10mg+Tablets/|url-status=dead}}</ref><ref name=BNF>{{cite book | last1=Joint Formulary Committee | title=British National Formulary (BNF) | publisher=Pharmaceutical Press | pages=224 }}</ref> It is generally preferred over [[benzodiazepine]]s because it does not activate the receptors that make drugs like [[alprazolam]] addictive.<ref name=Wil2018/>

Buspirone has no immediate [[anxiolytic]] effects, and hence has a delayed [[onset of action]]; its full clinical effectiveness may require 2–4 weeks to manifest itself.<ref name="SadockSadock2014">{{cite book| vauthors=Sadock BJ, Sadock VA, Ruiz P |title=Kaplan and Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry |url=https://books.google.com/books?id=IzGYBAAAQBAJ&pg=PT3211|date=22 September 2014|publisher=Wolters Kluwer Health |isbn=978-1-4698-8375-5|pages=3211–}}</ref> The drug is similarly effective in the treatment of [[generalized anxiety disorder]] (GAD) to benzodiazepines including [[diazepam]], alprazolam, [[lorazepam]], and [[clorazepate]].<ref name="pmid22608068" /> Buspirone is not known to be effective in the treatment of other anxiety disorders besides GAD.<ref name="pmid26535760">{{cite journal | vauthors=Howland RH | title=Buspirone: Back to the Future | journal=Journal of Psychosocial Nursing and Mental Health Services | volume=53 | issue=11 | pages=21–24 | date=November 2015 | pmid=26535760 | doi=10.3928/02793695-20151022-01 }}</ref>

===Other uses===

====Sexual dysfunction====
There is some evidence that buspirone on its own may be useful in the treatment of [[hypoactive sexual desire disorder]] (HSDD) in women.<ref name="pmid27916394">{{cite journal |vauthors=Goldstein I, Kim NN, Clayton AH, DeRogatis LR, Giraldi A, Parish SJ, Pfaus J, Simon JA, Kingsberg SA, Meston C, Stahl SM, Wallen K, Worsley R |title=Hypoactive Sexual Desire Disorder: International Society for the Study of Women's Sexual Health (ISSWSH) Expert Consensus Panel Review |journal=Mayo Clinic Proceedings |volume=92 |issue=1 |pages=114–128 |date=January 2017 |pmid=27916394 |doi=10.1016/j.mayocp.2016.09.018 |doi-access=free }}</ref> Buspirone may also be effective in treating [[antidepressant]]-induced [[sexual dysfunction]].<ref name=Wil2018/><ref name="pmid34247952">{{cite journal |vauthors=Trinchieri M, Trinchieri M, Perletti G, Magri V, Stamatiou K, Cai T, Montanari E, Trinchieri A |title=Erectile and Ejaculatory Dysfunction Associated with Use of Psychotropic Drugs: A Systematic Review |journal=The Journal of Sexual Medicine |volume=18 |issue=8 |pages=1354–1363 |date=August 2021 |pmid=34247952 |doi=10.1016/j.jsxm.2021.05.016 |s2cid=235798526 |quote=Buspirone, a non-benzodiazepine anxiolytic, have even demonstrated enhancement of sexual function in certain individuals. For this reason, they have been proposed as augmentation agents (antidotes) or substitution agents in patients with emerging sexual dysfunction after treatment with antidepressants.}}</ref><ref name="pmid31591339">{{cite journal |vauthors=Montejo AL, Prieto N, de Alarcón R, Casado-Espada N, de la Iglesia J, Montejo L |title=Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach |journal=Journal of Clinical Medicine |volume=8 |issue=10 |date=October 2019 |page=1640 |pmid=31591339 |pmc=6832699 |doi=10.3390/jcm8101640 |doi-access=free }}</ref>

====Miscellaneous====
Buspirone is not effective as a treatment for [[benzodiazepine withdrawal syndrome|benzodiazepine withdrawal]], [[barbiturate withdrawal]], or [[alcohol withdrawal]].<ref>{{cite journal | vauthors=Sontheimer DL, Ables AZ | title=Is imipramine or buspirone treatment effective in patients wishing to discontinue long-term benzodiazepine use? | journal=The Journal of Family Practice | volume=50 | issue=3 | pages=203 | date=March 2001 | pmid=11252203 }}</ref>

[[SSRI]] and [[SNRI]] antidepressants such as [[paroxetine]] and [[venlafaxine]], respectively, may cause jaw pain/jaw spasm reversible syndrome, although it is not common, and buspirone appears to be successful in treating antidepressant-induced [[bruxism]].<ref>{{cite journal | vauthors=Garrett AR, Hawley JS | title=SSRI-associated bruxism: A systematic review of published case reports | journal=Neurology. Clinical Practice | volume=8 | issue=2 | pages=135–141 | date=April 2018 | pmid=29708207 | pmc=5914744 | doi=10.1212/CPJ.0000000000000433 }}</ref><ref>{{cite journal| vauthors=Prisco V, Iannaccone T, Di Grezia G |date=1 April 2017 |title=Use of buspirone in selective serotonin reuptake inhibitor-induced sleep bruxism|journal=European Psychiatry|series=Abstract of the 25th European Congress of Psychiatry|volume=41 |pages=S855 |doi=10.1016/j.eurpsy.2017.01.1701 |s2cid=148816505 }}</ref>