Editing C-reactive protein (section)

== History and etymology ==
Discovered by [[William S. Tillett|Tillett]] and Francis in 1930,<ref name="pmid19869788">{{cite journal | vauthors = Tillett WS, Francis T | title = Serological Reactions in Pneumonia with a Non-Protein Somatic Fraction of Pneumococcus | journal = The Journal of Experimental Medicine | volume = 52 | issue = 4 | pages = 561–571 | date = September 1930 | pmid = 19869788 | pmc = 2131884 | doi = 10.1084/jem.52.4.561 }}</ref> it was initially thought that CRP might be a pathogenic secretion since it was elevated in a variety of illnesses, including [[cancer]].<ref name="Pepys"/> The later discovery of hepatic synthesis (made in the liver) demonstrated that it is a native protein.<ref name="isbn0-07-162591-7">{{cite book |vauthors=Kennelly PJ, Murray RF, Rodwell VW, Botham KM | title = Harper's illustrated biochemistry | publisher = McGraw-Hill Medical | year = 2009 | isbn = 978-0-07-162591-3 }}</ref><ref name="isbn1-4160-0287-1">{{cite book |vauthors=Pincus MR, McPherson RA, Henry JB | title = Henry's clinical diagnosis and management by laboratory methods | publisher = Saunders Elsevier | year = 2007 | isbn = 978-1-4160-0287-1 }}</ref><ref name="isbn1-4160-3285-1">{{cite book |vauthors=Ratey JJ, Noskin GA, Braun R, ((Hanley EN Jr)), McInnes IB, Ruddy S | title = Kelley's Textbook of Rheumatology: 2-Volume Set, Expert Consult: Online and Print (Textbook of Rheumatology (Kelley's)(2 Vol)) | publisher = Saunders | location = Philadelphia | year = 2008 | isbn = 978-1-4160-3285-4 }}</ref> Initially, CRP was measured using the [[quellung reaction]] which gave a positive or a negative result. More precise methods nowadays use [[dynamic light scattering]] after reaction with CRP-specific antibodies.<ref name="Bray 2016">{{cite journal | vauthors = Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, Yale SH | title = Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine | journal = WMJ | volume = 115 | issue = 6 | pages = 317–321 | date = December 2016 | pmid = 29094869 | url = https://wmjonline.org/wp-content/uploads/2016/115/6/317.pdf }}</ref>

CRP was so named because it was first identified as a substance in the serum of patients with acute inflammation that reacted with the [[cell wall]]  [[polysaccharide]] (C-polysaccharide) of [[pneumococcus]].<ref>{{cite journal | vauthors = Mold C, Nakayama S, Holzer TJ, Gewurz H, Du Clos TW | title = C-reactive protein is protective against Streptococcus pneumoniae infection in mice | journal = The Journal of Experimental Medicine | volume = 154 | issue = 5 | pages = 1703–1708 | date = November 1981 | pmid = 7299351 | pmc = 2186532 | doi = 10.1084/jem.154.5.1703 }}</ref>