Editing CYP2D6 (section)

== Gene ==

The gene is located on [[chromosome 22]]q13.1. near two cytochrome P450 [[pseudogene]]s (CYP2D7P and CYP2D8P).<ref>{{cite journal | vauthors = Ahmad HI, Afzal G, Jamal A, Kiran S, Khan MA, Mehmood K, Kamran Z, Ahmed I, Ahmad S, Ahmad A, Hussain J, Almas S | title = ''In Silico'' Structural, Functional, and Phylogenetic Analysis of Cytochrome (CYPD) Protein Family | journal = BioMed Research International | volume = 2021 | pages = 5574789 | date = 2021 | pmid = 34046497 | pmc = 8128545 | doi = 10.1155/2021/5574789 | doi-access = free }}</ref> Among them, CYP2D7P originated from CYP2D6 in a stem lineage of great apes and humans,<ref>{{cite journal | vauthors = Wang H, Tompkins LM | title = CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme | journal = Current Drug Metabolism | volume = 9 | issue = 7 | pages = 598–610 | date = September 2008 | pmid = 18781911 | pmc = 2605793 | doi = 10.2174/138920008785821710 }}</ref> the CYP2D8P originated from CYP2D6 in a stem lineage of [[Catarrhine]] and [[New World monkey]]s' stem lineage.<ref>{{cite journal | vauthors = Yasukochi Y, Satta Y | title = Evolution of the CYP2D gene cluster in humans and four non-human primates | journal = Genes & Genetic Systems | volume = 86 | issue = 2 | pages = 109–116 | date = 2011 | pmid = 21670550 | doi = 10.1266/ggs.86.109 | doi-access = free }}</ref> [[alternative splicing|Alternatively spliced]] transcript variants encoding different [[isoform]]s have been found for this gene.<ref>{{cite web| title = Entrez Gene: CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1565| access-date = 3 November 2017| archive-date = 8 March 2010| archive-url = https://web.archive.org/web/20100308050423/http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1565| url-status = live}}</ref>