Editing Cisapride (section)

==Medical uses==
Cisapride has been used for the treatment of [[gastroesophageal reflux disease]] (GERD). There is no evidence it is effective for this use in children.<ref name=GERD2010>{{cite journal | vauthors = Maclennan S, Augood C, Cash-Gibson L, Logan S, Gilbert RE | title = Cisapride treatment for gastro-oesophageal reflux in children | journal = The Cochrane Database of Systematic Reviews | issue = 4 | pages = CD002300 | date = April 2010 | volume = 2010 | pmid = 20393933 | doi = 10.1002/14651858.CD002300.pub2 | pmc = 7138252 | url = https://researchonline.lshtm.ac.uk/3792/1/3792.pdf }}</ref> It also increases gastric emptying in people with diabetic [[gastroparesis]]. Evidence for its use in [[constipation]] is not clear.<ref name=Cochrane2011>{{cite journal | vauthors = Aboumarzouk OM, Agarwal T, Antakia R, Shariff U, Nelson RL | title = Cisapride for intestinal constipation | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD007780 | date = January 2011 | pmid = 21249695 | doi = 10.1002/14651858.CD007780.pub2 }}</ref>

In many countries, it has been either withdrawn or had its indications limited because of reports of the side-effect [[long QT syndrome]], which may cause [[Heart arrhythmia|arrhythmia]]s. The [[Food and Drug Administration (United States)|U.S. Food and Drug Administration]] (FDA) issued a warning letter to doctors,<ref>{{cite web
|url = https://www.medscape.com/viewarticle/783710
|title = "Cardiac contraindications included in new FDA warnings about Propulsid"
|author = 
|date = January 25, 2000
|publisher = medscape.com
|accessdate = 10 May 2021
}}</ref> and cisapride was voluntarily removed from the U.S. market on July 14, 2000. Its use in Europe has also been limited.<ref name=GERD2010/> It was banned in India and in the Philippines in 2011.<ref name=ban>{{cite web|url=http://cdsco.nic.in/html/drugsbanned.html|title=Drugs banned in India|publisher=Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India|access-date=2013-09-17|url-status=dead|archive-url=https://web.archive.org/web/20150221053621/http://cdsco.nic.in/html/drugsbanned.html|archive-date=2015-02-21}}</ref>