Editing Cold Spring Harbor Laboratory (section)

==Research programs==
Research staff in CSHL's 52 laboratories numbers over 600, including [[postdoctoral researcher]]s; an additional 125 graduate students and 500 administrative and support personnel bring the total number of employees to over 1,200.<ref name="ReferenceA">{{Cite web |url=http://www.cshl.edu/images/stories/about_us/pdfs/2013-CSHL-factsheet.pdf |title=Archived copy |access-date=2014-03-21 |archive-url=https://web.archive.org/web/20150923211710/http://www.cshl.edu/images/stories/about_us/pdfs/2013-CSHL-factsheet.pdf |archive-date=2015-09-23 |url-status=dead }}</ref>

'''Cell biology and genomics'''<br/>
[[RNA interference]] (RNAi) and [[small RNA|small-RNA]] biology; [[DNA replication]]; [[RNA splicing]]; signal transduction; [[genome]] structure; [[non-coding RNAs]]; [[deep sequencing]]; [[single cell sequencing|single-cell sequencing]] and analytics; [[stem cell]] self-renewal and differentiation; [[chromatin]] dynamics; [[structural biology]]; advanced [[proteomics]];  [[mass spectrometry]]; advanced microscopy.<ref>{{Cite web |title=Genomics|url=https://www.cshl.edu/research/genomics/|access-date=2024-07-02 |website=Cold Spring Harbor Laboratory |language=en-US}}</ref>

'''Cancer research'''<br/>
Principal cancer types under study: breast, prostate, blood (leukemia, lymphoma); [[myelodysplastic syndrome]]; [[melanoma]]; liver; ovarian and cervical; lung; brain; pancreas.  Research foci: drug resistance; cancer [[genomics]]; [[tumor microenvironment]]; cancer metabolism; growth control in mammalian cells; transcriptional and post-transcriptional [[gene regulation]].<ref>{{Cite web |title=Cancer Center|url=
https://www.cshl.edu/research/cancer/|access-date=2024-07-02 |website=Cold Spring Harbor Laboratory |language=en-US}}</ref>

'''Neuroscience'''<br/>
Stanley Institute for Cognitive Genomics employs deep sequencing and other tools to study genetics underlying schizophrenia, bipolar disorder, and major depression. Swartz Center for the Neural Mechanisms of Cognition studies cognition in the normal brain as a baseline for understanding dysfunction in psychiatric and neurodegenerative disorders. Other research foci: autism genetics; mapping of the mammalian brain; neural correlates of decision making.<ref>{{Cite web |title=Stanley Institute for Cognitive Genomics |url=https://www.cshl.edu/research/neuroscience/stanley-institute-for-cognitive-genomics/ |access-date=2024-06-14 |website=Cold Spring Harbor Laboratory |language=en-US}}</ref>

'''Plant biology'''<ref name="Cold Spring Harbor Laboratory">{{Cite news|url=https://www.cshl.edu/research/plant-biology/#faculty|title=Plant Biology - Cold Spring Harbor Laboratory|work=Cold Spring Harbor Laboratory|access-date=2018-08-08|language=en-US}}</ref><br/>
Plant genome sequencing; [[epigenetics]] and stem cell fate; stem cell signalling; plant-environment interactions; using genetic insights to increase yield of staple crops, e.g., maize, rice, wheat; increase fruit yield in flowering plants, e.g., tomato.  Other initiatives: genetics of aquatic plants for [[biofuel]] development; lead role in building [[National Science Foundation]]'s [[iPlant Collaborative]]<ref>[[IPlant Collaborative]] and [http://www.iplantcollaborative.org/discover/powered-by-iplant] {{Webarchive|url=https://web.archive.org/web/20140322030156/http://www.iplantcollaborative.org/discover/powered-by-iplant|date=2014-03-22}}</ref> cyberinfrastructure. Much of this work takes place on 12 acres of farmland at the nearby CSHL Uplands Farm,<ref>{{Cite news|url=https://www.cshl.edu/research/plant-biology/uplands-farm/|title=Uplands Farm - Cold Spring Harbor Laboratory|work=Cold Spring Harbor Laboratory|access-date=2018-08-08|language=en-US}}</ref> where expert staff raise crops and ''Arabidopsis'' plants for studies. Seven CSHL faculty members conduct research primarily in plant biology - Drs. David Jackson, [[Zachary Lippman]], [[Robert A. Martienssen|Robert Martienssen]], Richard McCombie, Ullas Pedmale, Doreen Ware, and [[Thomas Gingeras]].<ref name="Cold Spring Harbor Laboratory"/>

'''Simons Center for Quantitative Biology'''<br/>
Genome assembly and validation; mathematical modeling and algorithm development; [[population genetics]]; applied statistical and machine learning; biomedical text-mining; [[computational genomics]]; cloud computing and Big Data.<ref>{{Cite web |title=Quantitate Biology |url=https://www.cshl.edu/research/quantitative-biology/ |access-date=2024-07-02 |website=Cold Spring Harbor Laboratory |language=en-US}}</ref>

'''COVID-19'''

Scientists at Cold Spring Harbor Laboratory (CSHL), Utah Health University, PEEL Therapeutics, and [[Weill Cornell Medicine]] worked to examine the possible function of NETs in [[Coronavirus disease 2019|COVID-19]], gather blood samples from 33 hospitalized individuals, as well as autopsy tissue. [[Neutrophil extracellular traps|Neutrophil Extracellular Traps]] (NETs) are a form of protection which is utilized by the immune system against certain pathogens.<ref>{{Cite web|date=29 June 2020|title=New evidence for how blood clots may form in very ill COVID-19 patients|url=https://www.prnewswire.com/news-releases/new-evidence-for-how-blood-clots-may-form-in-very-ill-covid-19-patients-301085133.html|access-date=21 July 2020|website=Cision PR Newswire}}</ref>