Editing Delta cell (section)

==Clinical significance==
A tumor of the delta cells is called a "[[somatostatinoma]]".

When a person is infected with ''[[H. pylori]]'' the lower region of the stomach, the [[Pyloric antrum|antrum]], is predominantly inflamed. This is where most of the δ-cells in the stomach are. The bacteria produce a cloud of ammonia around themselves using [[urease]] to protect them from the stomach acid; however, this reacts with the acid producing ammonium which is toxic to cells. This leads to many of the δ-cells dying, an effect that is further compounded by the low [[PD-L1]] expression on the δ-cells as compared to gastric G cells (resulting in higher susceptibility of δ-cells to inflammatory responses).<ref>{{cite journal | vauthors = Mommersteeg MC, Yu BT, van den Bosch TP, von der Thüsen JH, Kuipers EJ, Doukas M, Spaander MC, Peppelenbosch MP, Fuhler GM | title = Constitutive programmed death ligand 1 expression protects gastric G-cells from Helicobacter pylori-induced inflammation | journal = Helicobacter | volume = 27 | issue = 5 | pages = e12917 | date = October 2022 | pmid = 35899973 | doi = 10.1111/hel.12917| pmc = 9542424 }}</ref> In turn, this results in a lower level of [[somatostatin]] being secreted and consequently higher release of [[gastrin]] and stomach acid. This, combined with the damage from ammonium, leads to ulceration of the stomach wall.<ref>{{cite journal | vauthors = Liu Y, Vosmaer GD, Tytgat GN, Xiao SD, Ten Kate FJ | title = Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis | journal = Journal of Clinical Pathology | volume = 58 | issue = 9 | pages = 927–931 | date = September 2005 | pmid = 16126872 | pmc = 1770830 | doi = 10.1136/jcp.2003.010710 }}</ref>