Editing Endochondral ossification (section)

==Formation of the cartilage model==
The initiation of endochondral ossification starts by proliferation and condensation of [[mesenchymal cells]] in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into [[chondroblasts]], which actively synthesize cartilage matrix components. Thus, the initial hyaline cartilage template is formed, which has the same basic shape and outline as the future bone.<ref name=Paw>{{cite book |last1=Pawlina |first1=Wojciech |title=Histology: a text and atlas: with correlated cell and molecular biology |date=2024 |publisher=Wolters Kluwer |isbn=9781975181574 |edition=9th |url=https://www.lww.co.uk/9781975181574/histology-a-text-and-atlas/}}</ref>

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|+ This hyaline cartilage template expands through both:<ref name="Paw" /><ref name="Jun">{{cite book |last1=Mescher |first1=Anthony L. |title=Junqueira's Basic Histology: Text and Atlas |date=2023 |publisher=McGraw-Hill Education |isbn=978-1264930395 |edition=17th |url=https://www.mhprofessional.com/junqueira-s-basic-histology-text-and-atlas-seventeenth-edition-9781264930395-usa |language=en}}</ref>
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!  !! Interstitial growth !! Appositional growth
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| Cellular protagonists || [[Chondrocytes]] present within the existing cartilage. || [[Chondroblasts]] that develop from the perichondrium.
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| Mechanism || Chondrocytes proliferate and lay down matrix. || Chondroblasts differentiate into chondrocytes and lay down matrix.
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| Site of expansion || From within. || From the external surface of existing cartilage.
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| Outcome || Increase in length. || Increase in width and thickness.
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