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Endosome
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== Function == {{Further|Endocytic cycle}} Endosomes provide an environment for material to be sorted before it reaches the degradative lysosome.<ref name="endo1" /> For example, [[low-density lipoprotein]] (LDL) is taken into the cell by binding to the [[LDL receptor]] at the cell surface. Upon reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. The LDL remains in the endosome and is delivered to lysosomes for processing. LDL dissociates because of the slightly acidified environment of the early endosome, generated by a vacuolar membrane proton pump [[V-ATPase]]. On the other hand, [[epidermal growth factor]] (EGF) and the EGF receptor have a pH-resistant bond that persists until it is delivered to lysosomes for their degradation. The [[mannose 6-phosphate receptor]] carries [[Ligand (biochemistry)|ligands]] from the Golgi destined for the lysosome by a similar mechanism.
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