Editing Equol (section)

== History ==
(''S'')-Equol was first isolated from horse urine in 1932,<ref>{{cite journal|last=Marrian|first=GF|author2=Haslewood, GA |title=Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares' urine |journal=The Biochemical Journal|year=1932|volume=26|issue=4|pages=1227–32|pmid=16744928|pmc=1261026|doi=10.1042/bj0261227}}</ref> and the name was suggested by this equine connection.<ref name= Setchell >{{cite journal|last=Setchell|first=KD|author2=Clerici, C |title=Equol: history, chemistry, and formation |journal=The Journal of Nutrition|date=July 2010|volume=140|issue=7|pages=1355S–62S|pmid=20519412|doi=10.3945/jn.109.119776|pmc=2884333}}</ref> Since then, equol has been found in the urine or plasma of many other animal species, although these animals have significant differences in their ability to metabolize daidzein into equol.<ref name= Setchell/> In 1980, scientists reported the discovery of equol in humans.<ref>{{cite journal|last=Axelson|first=M |author2=Kirk, DN |author3=Farrant, RD |author4=Cooley, G |author5=Lawson, AM |author6=Setchell, KD|title=The identification of the weak oestrogen equol [7-hydroxy-3-(4'-hydroxyphenyl)chroman] in human urine |journal=The Biochemical Journal|date=1982-02-01|volume=201|issue=2|pages=353–7|pmid=7082293|pmc=1163650 |doi=10.1042/bj2010353}}</ref>  The ability of (''S'')-equol to play a role in the treatment of [[Estrogen and neurodegenerative diseases|estrogen]]- or [[Androgen-dependent condition|androgen-mediated]] diseases or disorders was first proposed in 1984.<ref name=pmid6383008>{{cite journal|last=Setchell|first=KD |author2=Borriello, SP |author3=Hulme, P |author4=Kirk, DN |author5=Axelson, M|s2cid=4467689 |title=Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease |journal=[[The American Journal of Clinical Nutrition]]|date=September 1984|volume=40|issue=3|pages=569–78|pmid=6383008|doi=10.1093/ajcn/40.3.569 }}</ref>