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Essential thrombocythemia
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==Signs and symptoms== Most people with essential thrombocythemia are [[asymptomatic|without symptoms]] at the time of diagnosis, which is usually made after noting an elevated platelet level on a routine [[complete blood count]] (CBC).<ref name="paed">{{cite journal |last1=Fu |first1=R |last2=Zhang |first2=L |last3=Yang |first3=R |title=Paediatric essential thrombocythaemia: clinical and molecular features, diagnosis and treatment |journal=British Journal of Haematology |date=November 2013 |volume=163 |issue=3 |pages=295β302 |doi=10.1111/bjh.12530 |pmid=24032343|s2cid=10880402 }}</ref> The most common symptoms are bleeding (due to dysfunctional platelets), [[thrombosis|blood clots]] (e.g., [[deep vein thrombosis]] or [[pulmonary embolism]]), fatigue, headache, nausea, vomiting, abdominal pain, visual disturbances, dizziness, [[Syncope (medicine)|fainting]], and numbness in the extremities; the most common signs are [[leukocytosis|increased white blood cell count]], [[anaemia|reduced red blood cell count]], and an [[splenomegaly|enlarged spleen]].<ref name="paed"/><ref>{{cite journal |last1=Frewin |first1=R |last2=Dowson |first2=A |title=Headache in essential thrombocythaemia.|journal=International Journal of Clinical Practice |date=October 2012 |volume=66 |issue=10 |pages=976β983 |doi=10.1111/j.1742-1241.2012.02986.x |pmid=22889110 |pmc=3469735}}</ref><ref>{{cite journal |last=Tefferi |first=A |title=Annual Clinical Updates in Hematological Malignancies: a continuing medical education series: polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management. |journal=American Journal of Hematology |date=March 2011 |volume=86 |issue=3 |pages=292β301 |doi=10.1002/ajh.21946 |pmid=21351120|s2cid=205293800 }}</ref>
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