Editing Glycated hemoglobin (section)

==Terminology==
[[Glycation|Glycated]] hemoglobin is preferred over [[glycosylation|glycosylated]] hemoglobin to reflect the correct (non-enzymatic) process. Early literature often used ''glycosylated'' as it was unclear which process was involved until further research was performed. The terms are still sometimes used interchangeably in English-language literature.<ref>{{cite journal
|title=Glycated or glycosylated?
|author=Oliwia Witczak, Trine B. Haugen
|date=25 November 2014
|journal=[[Journal of the Norwegian Medical Association]]
|volume=134
|issue=22
|pages=2179
|pmid=25423986
|doi=10.4045/tidsskr.14.0172
|doi-access=free
|url=https://tidsskriftet.no/en/2014/11/glycated-or-glycosylated
|access-date=5 December 2018
|url-status=live
|archive-url=https://web.archive.org/web/20181205145806/https://tidsskriftet.no/en/2014/11/glycated-or-glycosylated
|archive-date=5 December 2018
|quote=Hospitals should ensure that the correct term for HbA1c — glycated haemoglobin — is now to be found in laboratory manuals.
}}</ref>

The naming of HbA1c derives from hemoglobin type A being separated on [[ion chromatography|cation exchange chromatography]]. The first fraction to separate, probably considered to be pure hemoglobin A, was designated HbA0, and the following fractions were designated HbA1a, HbA1b, and HbA1c, in their order of [[elution]]. Improved separation techniques have subsequently led to the isolation of more [[wikt:subfraction|subfraction]]s.<ref name="pmid9732983">{{cite journal |vauthors=Peterson KP, Pavlovich JG, Goldstein D, Little R, England J, Peterson CM |title=What is hemoglobin A1c? An analysis of glycated hemoglobins by electrospray ionization mass spectrometry |journal=[[Clinical Chemistry (journal)|Clinical Chemistry]] |volume=44 |issue=9 |year=1998 |pages=1951–8 |pmid=9732983 |doi=10.1093/clinchem/44.9.1951 |doi-access=free |url=https://academic.oup.com/clinchem/article/44/9/1951/5642934 |access-date=2024-06-21 |url-status=live |archive-url=https://web.archive.org/web/20150923223202/http://www.clinchem.org/content/44/9/1951.long |archive-date=2015-09-23}}</ref>