Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Glycogenesis
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Steps== [[File:Glycogenesis.png|thumb]] * [[Glucose]] is converted into [[glucose 6-phosphate]] by the action of [[glucokinase]] or [[hexokinase]] with conversion of ATP to ADP. * Glucose-6-phosphate is converted into [[glucose-1-phosphate]] by the action of [[phosphoglucomutase]], passing through the obligatory intermediate [[glucose-1,6-bisphosphate]]. * Glucose-1-phosphate is converted into [[UDP-glucose]] by the action of the enzyme [[UTP—glucose-1-phosphate uridylyltransferase|UDP-glucose pyrophosphorylase]]. [[Pyrophosphate]] is formed, which is later hydrolysed by [[pyrophosphatase]] into two phosphate molecules. * The enzyme [[glycogenin]] is needed to create initial short glycogen chains, which are then lengthened and branched by the other enzymes of glycogenesis. [[Glycogenin]], a homodimer, has a [[tyrosine]] residue on each subunit that serves as the anchor for the reducing end of glycogen. Initially, about seven UDP-glucose molecules are added to each tyrosine residue by glycogenin, forming α(1→4) bonds. * Once a chain of seven glucose monomers is formed, [[glycogen synthase]] binds to the growing glycogen chain and adds UDP-glucose to the 4-hydroxyl group of the glucosyl residue on the non-reducing end of the glycogen chain, forming more α(1→4) bonds in the process. * Branches are made by [[glycogen branching enzyme]] (also known as amylo-α(1:4)→α(1:6)transglycosylase), which transfers the end of the chain onto an earlier part via α-1:6 glycosidic bond, forming branches, which further grow by addition of more α-1:4 glycosidic units. {| class="toccolours collapsible collapsed" width="100%" style="text-align:left" ! Metabolism of common [[monosaccharide]]s, including [[glycolysis]], [[gluconeogenesis]], glycogenesis and [[glycogenolysis]] |- |[[File:Metabolism of common monosaccharides, and related reactions.png|none|1000px]] |}
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)