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GroEL
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== Discovery == Not much is known about the function of HSP60. [[Mammal]]ian HSP60 was first reported as a mitochondrial P1 protein. It was subsequently [[cloned]] and [[sequenced]] by [[Radhey Gupta]] and coworkers.<ref name=two/> The amino acid sequence showed a strong homology to GroEL. It was initially believed that HSP60 functioned only in the [[mitochondria]] and that there was no equivalent protein located in the [[cytoplasm]]. Recent discoveries have discredited this claim and have suggested that there is a recognizable difference between HSP60 in the mitochondria and in the cytoplasm.<ref name=one>{{cite journal |vauthors=Itoh H, Komatsuda A, Ohtani H, etal |title=Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration |journal=Eur. J. Biochem. |volume=269 |issue=23 |pages=5931β8 |date=December 2002 |pmid=12444982 |doi=10.1046/j.1432-1033.2002.03317.x}}</ref> A similar protein structure exists in the [[chloroplast]] of certain plants. This protein presence provides evidence for the evolutionary relationship of the development of the mitochondria and the chloroplast by means of [[endosymbiosis]].<ref name=two>{{cite journal |author=Gupta RS |title=Evolution of the chaperonin families (Hsp60, Hsp10 and Tcp-1) of proteins and the origin of eukaryotic cells |journal=Mol. Microbiol. |volume=15 |issue=1 |pages=1β11 |date=January 1995 |pmid=7752884 |doi=10.1111/j.1365-2958.1995.tb02216.x |doi-access=free }}</ref>
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