Editing Hypertriglyceridemia (section)

==Signs and symptoms==
Most people with elevated triglycerides experience no symptoms. Some forms of primary hypertriglyceridemia can lead to specific symptoms: both familial chylomicronemia and primary [[Combined hyperlipidemia|mixed hyperlipidemia]] include skin symptoms (eruptive [[xanthoma]]), eye abnormalities ([[lipaemia retinalis]]), [[hepatosplenomegaly]] (enlargement of the [[liver]] and [[spleen]]), and neurological symptoms. Some experience attacks of abdominal pain that may be mild episodes of pancreatitis. Eruptive xanthomas are 2–5&nbsp;mm papules, often with a red ring around them, that occur in clusters on the skin of the trunk, buttocks and extremities.<ref name="Yuan2007">{{cite journal | vauthors = Yuan G, Al-Shali KZ, Hegele RA | title = Hypertriglyceridemia: its etiology, effects and treatment | journal = CMAJ | volume = 176 | issue = 8 | pages = 1113–1120 | date = April 2007 | pmid = 17420495 | pmc = 1839776 | doi = 10.1503/cmaj.060963 }}</ref> [[Familial dysbetalipoproteinemia]] causes larger, tuberous xanthomas; these are red or orange and occur on the elbows and knees. Palmar crease xanthomas may also occur.<ref name="CPG2012">{{cite journal | vauthors = Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, Stalenhoef AF |author4-link=Ira Goldberg | title = Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 97 | issue = 9 | pages = 2969–2989 | date = September 2012 | pmid = 22962670 | pmc = 3431581 | doi = 10.1210/jc.2011-3213 }}</ref><ref name="Yuan2007" />

The diagnosis is made on [[blood test]]s, often performed as part of [[Screening (medicine)|screening]]. Once diagnosed, other blood tests are usually required to determine whether the raised triglyceride level is caused by other underlying disorders ("secondary hypertriglyceridemia") or whether no such underlying cause exists ("primary hypertriglyceridemia"). There is a hereditary predisposition to both primary and secondary hypertriglyceridemia.<ref name=CPG2012/>
[[File:Fat triglyceride shorthand formula.svg|thumb|right|[[Triglyceride]], which cause hypertriglyceridemia at high level]]

[[Acute pancreatitis]] may occur in people whose triglyceride levels are above 1000&nbsp;mg/dL (11.3&nbsp;mmol/L).<ref name=CPG2012/><ref name=Yuan2007/><ref name="Tsuang2009">{{cite journal | vauthors = Tsuang W, Navaneethan U, Ruiz L, Palascak JB, Gelrud A | title = Hypertriglyceridemic pancreatitis: presentation and management | journal = The American Journal of Gastroenterology | volume = 104 | issue = 4 | pages = 984–991 | date = April 2009 | pmid = 19293788 | doi = 10.1038/ajg.2009.27 | s2cid = 24193233 }}</ref> Hypertriglyceridemia is associated with 1–4% of all cases of pancreatitis. The symptoms are similar to pancreatitis secondary to other causes, although the presence of xanthomas or risk factors for hypertriglyceridemia may offer clues.<ref name=Tsuang2009/>