Editing Internal transcribed spacer (section)

== Across life domains ==
In [[bacteria]] and [[archaea]], there is a single ITS, located between the [[16S ribosomal RNA|16S]] and [[23S ribosomal RNA|23S]] rRNA genes. Conversely, there are two ITSs in [[eukaryotes]]: '''ITS1''' is located between [[18S ribosomal RNA|18S]] and [[5.8S ribosomal RNA|5.8S]] rRNA genes, while '''ITS2''' is between 5.8S and [[28S ribosomal RNA|28S]] (in [[opisthokont]]s, or 25S in plants) rRNA genes. ITS1 corresponds to the ITS in bacteria and archaea, while ITS2 originated as an insertion that interrupted the ancestral 23S rRNA gene.<ref>{{Cite journal | doi = 10.1038/35080045| pmid = 11433365| title = The function and synthesis of ribosomes| journal = Nature Reviews Molecular Cell Biology| volume = 2| issue = 7| pages = 514–520| year = 2001| last1 = Lafontaine | first1 = D. L. J. | last2 = Tollervey | first2 = D. | hdl = 1842/729| s2cid = 2637106| hdl-access = free}}</ref><ref name="Rogers2011">{{cite book|author=Scott Orland Rogers|title=Integrated Molecular Evolution|url=https://books.google.com/books?id=xywnbQMKzXwC&pg=PA66|access-date=9 March 2015|date=27 July 2011|publisher=CRC Press|isbn=978-1-4398-1995-1|pages=65–66}}</ref>