Editing Invagination (section)

== History ==
The process of tissue invagination has fascinated scientists for over a century and a half. Since the beginning, scientists have tried to understand the process of invagination as a mechanical process resulting from forces acting in the [[embryo]].<ref>Ettensohn, Charles A. 1985. “Mechanisms of Epithelial Invagination.” ''The Quarterly Review of Biology'' 60 (3): 289–307. <nowiki>https://doi.org/10.1086/414426</nowiki>.</ref> For example, the Swiss biologist [[Wilhelm His Sr.|Wilhelm His]], observing the invagination of the [[Chicken as biological research model|chick]] neural tube, experimented with modeling this process using sheets of different materials and suggested that pushing forces from the lateral edges of the [[neural plate]] might drive its invagination.<ref name=":0">D. S., Vijayraghavan, and Davidson L. A. 2017. “Mechanics of Neurulation: From Classical to Current Perspectives on the Physical Mechanics That Shape, Fold, and Form the Neural Tube.” ''Birth Defects Research'' 109 (2): 153–68. <nowiki>https://doi.org/10.1002/bdra.23557</nowiki>.</ref> Scientists throughout the next century have speculated on the mechanisms of invagination, often making models of this process using either physical analogs,<ref>Lewis, Warren H. 1947. “Mechanics of Invagination.” ''The Anatomical Record'' 97 (2): 139–56. <nowiki>https://doi.org/10.1002/ar.1090970203</nowiki>.</ref> or, especially in recent years, [[Mathematical model|mathematical]] and [[Computer simulation|computational modeling]].