Editing Left ventricular hypertrophy (section)

==Causes==
While ventricular hypertrophy [[athletic heart syndrome|occurs naturally]] as a reaction to [[aerobic exercise]] and [[strength training]], it is most frequently referred to as a pathological reaction to [[cardiovascular disease]], or [[high blood pressure]].<ref name="titleAsk the doctor: Left Ventricular Hypertrophy">{{cite web |url=http://www.clevelandclinic.org/heartcenter/pub/guide/askdoctor/lvh.htm |title=Ask the doctor: Left Ventricular Hypertrophy |access-date=2007-12-07 }}</ref> It is one aspect of [[ventricular remodeling]].

While LVH itself is not a disease, it is usually a marker for disease involving the heart.<ref name="pmid18030317">{{cite journal | vauthors = Meijs MF, Bots ML, Vonken EJ, Cramer MJ, Melman PG, Velthuis BK, van der Graaf Y, Mali WP, Doevendans PA | display-authors = 6 | title = Rationale and design of the SMART Heart study: A prediction model for left ventricular hypertrophy in hypertension | journal = Netherlands Heart Journal | volume = 15 | issue = 9 | pages = 295–298 | year = 2007 | pmid = 18030317 | pmc = 1995099 | doi = 10.1007/BF03086003 }}</ref>  Disease processes that can cause LVH include any disease that increases the [[afterload]] that the heart has to contract against, and some primary diseases of the [[heart muscle|muscle of the heart]].{{citation needed|date=February 2021}}
Causes of increased afterload that can cause LVH include [[aortic stenosis]], [[aortic insufficiency]] and [[hypertension]]. Primary disease of the muscle of the heart that cause LVH are known as [[hypertrophic cardiomyopathy|hypertrophic cardiomyopathies]], which can lead into heart failure.{{citation needed|date=February 2021}}

Long-standing [[mitral insufficiency]] also leads to LVH as a compensatory mechanism.{{citation needed|date=February 2021}}

LV mass increases with [[ageing]].<ref name=":0" />

Associated genes include [[OGN (gene)|OGN]], osteoglycin.<ref name="pmid18443592">{{cite journal | vauthors = Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA | display-authors = 6 | title = Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass | journal = Nature Genetics | volume = 40 | issue = 5 | pages = 546–552 | date = May 2008 | pmid = 18443592 | pmc = 2742198 | doi = 10.1038/ng.134 }}</ref>