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Methaqualone
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== Medical use == The sedative–hypnotic activity of methaqualone was recognized in 1955. Its use peaked in the early 1970s for the treatment of [[insomnia]], and as a [[sedative]] and [[muscle relaxant]]. Methaqualone was not recommended for use while pregnant and is in [[pregnancy category#United States|pregnancy category D]].<ref>{{Cite web| work = TheDrugSafety.com |title=Methaqualone in Pregnancy and Breastfeeding|url=http://thedrugsafety.com/methaqualone/|access-date=15 August 2012|archive-url=https://web.archive.org/web/20121002101854/http://thedrugsafety.com/methaqualone/|archive-date=2012-10-02|url-status=dead}}</ref> Similar to other [[GABAergic]] agents, methaqualone will produce tolerance and physical dependence with extended periods of use.<ref>{{cite journal |vauthors=Suzuki T, Koike Y, Chida Y, Misawa M |date=April 1988 |title=Cross-physical dependence of several drugs in methaqualone-dependent rats |journal=Japanese Journal of Pharmacology |volume=46 |issue=4 |pages=403–410 |doi=10.1254/jjp.46.403 |pmid=3404770 |doi-access=free}}</ref>
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