Editing Monocyte (section)

==Structure==
Monocytes are [[amoeba|amoeboid]] in appearance, and have nongranulated [[cytoplasm]].<ref>{{cite journal |last1=Nichols |first1=Barbara A. |last2=Bainton |first2=Dorothy Ford |last3=Farquhar |first3=Marilyn G. |date=1 August 1971 |title=Differentiation of monocytes |journal=[[Journal of Cell Biology]] |volume=50 |issue=2 |pages=498–515 |doi=10.1083/jcb.50.2.498 |pmc=2108281 |pmid=4107019}}</ref> Thus they are classified as [[agranulocyte]]s, although they might occasionally display some [[azurophil granules]] and/or [[vacuole]]s. With a diameter of 15–22 [[Micrometre|μm]], monocytes are the largest cell type in [[peripheral blood]].<ref name="w192">{{cite journal | last1=Palmer | first1=L. | last2=Briggs | first2=C. | last3=McFadden | first3=S. | last4=Zini | first4=G. | last5=Burthem | first5=J. | last6=Rozenberg | first6=G. | last7=Proytcheva | first7=M. | last8=Machin | first8=S. J. | title=ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features | journal=International Journal of Laboratory Hematology | volume=37 | issue=3 | date=2015 | issn=1751-5521 | doi=10.1111/ijlh.12327 | pages=287–303| pmid=25728865 }}</ref><ref>{{cite journal|url=http://www.histology.leeds.ac.uk/blood/blood_wbc.php|title=The Leeds Histology Guide|first1=Paxton|last1=Steve|first2=Peckham|last2=Michelle|first3=Knibbs|last3=Adele|date=28 April 2018|website=leeds.ac.uk|access-date=28 April 2018|url-status=live|archive-url=https://web.archive.org/web/20171011015456/http://www.histology.leeds.ac.uk/blood/blood_wbc.php|archive-date=11 October 2017}}</ref>  Monocytes are mononuclear cells and the ellipsoidal nucleus is often lobulated/indented, causing a bean-shaped or kidney-shaped appearance.<ref name="m118">{{cite journal | last=Zini | first=Gina | title=How I investigate difficult cells at the optical microscope | journal=International Journal of Laboratory Hematology | volume=43 | issue=3 | date=2021 | issn=1751-5521 | doi=10.1111/ijlh.13437 | pages=346–353| pmid=33342036 }}</ref> Monocytes compose 2% to 10% of all leukocytes in the human body.