Editing Mononuclear phagocyte system (section)

==Cell types and locations==

The [[spleen]] is the second largest unit of the mononuclear phagocyte system. The monocyte is formed in the bone marrow and transported by the blood; it migrates into the tissues, where it transforms into a histiocyte or a macrophage.

Macrophages are diffusely scattered in the connective tissue and in liver (Kupffer cells), spleen and lymph nodes (sinus histiocytes), lungs (alveolar macrophages), and central nervous system (microglia). The half-life of blood monocytes is about 1 day, whereas the life span of tissue macrophages is several months or years. The mononuclear phagocyte system is part of both humoral and cell-mediated immunity. The mononuclear phagocyte system has an important role in defense against microorganisms, including mycobacteria, fungi, bacteria, protozoa, and viruses. Macrophages remove senescent erythrocytes, leukocytes, and [[megakaryocyte]]s by [[phagocytosis]] and digestion.

{| class="wikitable",
! Cell Name || Location
|-
| [[Adipose tissue macrophages]] || [[Adipose tissue]]
|-
| [[Monocyte]] || [[Bone Marrow]]/[[Blood]]
|-
| [[Kupffer cell]] || [[Liver]]
|-
| [[Medulla of lymph node|Sinus histiocytes]] || [[Lymph node]]
|-
| [[Alveolar macrophage]] (dust cell) || [[Pulmonary alveolus]] of [[Lungs]]
|-
| [[Macrophage#Tissue macrophages|Tissue macrophages]] (Histiocyte) leading to [[Giant cell]]s || [[Connective Tissues]]
|-
| [[Langerhans cell]] || [[Skin]] and [[Mucosa]]
|-
| [[Microglia]] || [[Central Nervous System]]
|-
| [[Hofbauer cell]]  || [[Placenta]]
|-
| [[Intraglomerular mesangial cell]]<ref>{{cite book |last=Lote |first=Christopher J. |title= Principles of Renal Physiology, 5th edition|publisher=Springer |page=37}}</ref> || [[Kidney]]
|-
| [[Epithelioid cell|Epithelioid]] histiocyte  || [[Granulomas]]
|-
| [[Red pulp|Red Pulp Macrophage]] ([[Sinusoid (blood vessel)|Sinusoidal]] lining cells) || Red pulp of [[Spleen]]
|-
| Peritoneal macrophages   || [[Peritoneal cavity]]
|-
| [[Osteoclast]]  || [[Bone]]
|-
|}