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Myxedema
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==Signs and symptoms== {{Multiple image <!-- Essential parameters --> | align = right | direction = horizontal | width = 175 <!-- Image 1 --> | image1 = Myxedema face.png | caption1 = Man with myxedema or severe hypothyroidism showing an expressionless face, puffiness around the eyes and pallor <!-- Image 2 --> | image2 = Myxedema standing.png | caption2 = Additional findings include swelling of the arms and legs and significant [[ascites]].}} [[File:BASA-3K-7-529-35(7)-Myxedema.jpg|thumb|Woman with myxedema, Bulgaria, 1930s.]] Myxedema's characteristic physical sign is [[non-pitting edema]], in contrast to [[pitting edema]].<ref>{{Cite journal |last1=Bhutada |first1=Abhishek S. |last2=Kodankandath |first2=Thomas V. |date=July 2022 |title=Clinical Manifestations of Severe Untreated Hypothyroidism |journal=Cureus |volume=14 |issue=7 |pages=e26595 |doi=10.7759/cureus.26595 |doi-access=free |issn=2168-8184 |pmc=9354917 |pmid=35936163}}</ref> Myxedema can also occur in the lower leg ([[pretibial myxedema]]) and behind the eyes ([[exophthalmos]]).{{cn|date=December 2024}} Severe cases, requiring hospitalization can exhibit signs of hypothermia, hypoglycemia, hypotension, respiratory depression, and coma.{{cn|date=December 2024}}
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