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Naproxen
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== Medical uses == Naproxen's medical uses are related to its mechanism of action as an anti-inflammatory compound.<ref name="Naprosyn label" /> Naproxen is used to treat a variety of inflammatory conditions and symptoms that are due to excessive [[inflammation]], such as [[pain]] and [[fever]] (naproxen has fever-reducing, or [[antipyretic]], properties in addition to its anti-inflammatory activity).<ref name="Naprosyn label" /> Naproxen's anti-inflammatory properties may relieve pain caused by inflammatory conditions such as [[migraine]], [[osteoarthritis]], [[kidney stones]], [[rheumatoid arthritis]], [[psoriatic arthritis]], [[gout]], [[ankylosing spondylitis]], [[menstrual cramp]]s, [[tendinitis]], and [[bursitis]].<ref name="drugs" >{{cite web|url=https://www.drugs.com/naproxen.html|title=Naproxen|publisher=Drugs.com|date=2017|access-date=7 February 2017}}</ref> Naproxen has also proven effective for acute post-operative pain.<ref name=":0" /> Naproxen sodium is used as a "bridge therapy" in [[medication overuse headache|medication-overuse headache]] to slowly take patients off other medications.<ref name="Chronic HA">{{cite journal | vauthors = Garza I, Schwedt TJ | title = Diagnosis and management of chronic daily headache | journal = Seminars in Neurology | volume = 30 | issue = 2 | pages = 154β166 | date = April 2010 | pmid = 20352585 | doi = 10.1055/s-0030-1249224 | publisher = WebMD LLC | doi-access = free }}</ref> ===Available formulations=== Naproxen sodium is available as both an immediate-release and an extended-release tablet. The extended-release formulations (sometimes called "sustained release", or "enteric coated") take longer to take effect than the immediate-release formulations and therefore are less useful when immediate pain relief is desired. Extended-release formulations are more useful for the treatment of chronic, or long-lasting, conditions, in which long-term pain relief is desirable.<ref name="L490 Pill Identification"/> <gallery mode="nolines" widths="170" perrow="3"> File:Naproxen2016.jpg|250{{nbsp}}mg tablet of naproxen File:Naproxen.JPG|220{{nbsp}}mg tablet of naproxen sodium. Imprint L490 (upside-down). Round, light blue tablet<ref name="L490 Pill Identification">{{cite web|title=L490 (Naproxen 220 mg)|url=https://www.drugs.com/imprints/l490-13081.html|website=drugs.com|access-date=17 May 2017}}</ref> File:Teva-naproxen-ec-500.png|Naproxen extended release 500{{nbsp}}mg, back and front </gallery> ===Pregnancy and lactation=== As with all non-steroidal anti-inflammatory medications (NSAIDs), naproxen use should be avoided in pregnancy due to the importance of prostaglandins in vascular and renal function in the fetus. NSAIDs should especially be avoided in the third trimester. Small amounts of naproxen are excreted in breast milk.<ref name=drugs/> However, adverse effects are uncommon in infants breastfed from a mother taking naproxen.<ref name="LactMed">{{cite web|title=LACTMED: NAPROXEN|url=https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~H9DD3g:1|website=TOXNET|publisher=NIH|access-date=21 July 2017}}</ref>
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