Editing Necrosis (section)

== Necrosis in Ageing and Chronic disease ==
Emerging research led by [[Carina Kern|Dr Carina Kern]] in 2025 has shown that necrosis is a potential key target as a driver of [[Ageing|aging]] and chronic disease<ref>{{Cite journal |last=Kern |first=Carina |last2=Bonventre |first2=Joseph V. |last3=Justin |first3=Alexander W. |last4=Kashani |first4=Kianoush |last5=Reynolds |first5=Elizabeth |last6=Siew |first6=Keith |last7=Davis |first7=Bill |last8=Karakoy |first8=Halime |last9=Grzesiak |first9=Nikodem |last10=Bailey |first10=Damian Miles |date=2025-05-29 |title=Necrosis as a fundamental driver of loss of resilience and biological decline: what if we could intervene? |url=https://www.nature.com/articles/s41388-025-03431-y |journal=Oncogene |language=en |pages=1–12 |doi=10.1038/s41388-025-03431-y |issn=1476-5594}}</ref>. Feed back loops created by spillage from necrotic cells affects wider tissues leading to damage and loss of resilience over time. This is accompanied by maladaptive wound healing that drives chronic [[inflammation]], [[Cellular senescence|senescent cell]] accumulation and [[fibrosis]]. [https://doi.org/10.1038/s41388-025-03431-y]