Editing Neostigmine (section)

== Medical uses ==
It is used to improve muscle tone in people with [[myasthenia gravis]], and also to reverse the effects of non-[[depolarization|depolarizing]] [[muscle relaxant]]s such as [[rocuronium]] and [[vecuronium]] at the end of an operation.<ref name = "Neely_2022">{{cite book | chapter-url= https://www.ncbi.nlm.nih.gov/books/NBK470596/ | pmid=29261883 | year=2022 | vauthors = Neely GA, Sabir S, Kohli A | chapter = Neostigmine | title = StatPearls [Internet] | location = Treasure Island (FL) | publisher = StatPearls Publishing }}</ref><ref>{{cite web | url=https://www.drugs.com/cdi/neostigmine-injection.html | title=Neostigmine Injection: Indications, Side Effects, Warnings | work = Drugs.com }}</ref>

Another indication for use is the [[conservative management]] of acute colonic pseudo-obstruction, or [[Ogilvie syndrome|Ogilvie's syndrome]], in which patients get massive colonic dilatation in the absence of a true mechanical obstruction.<ref>{{cite journal | vauthors = Maloney N, Vargas HD | title = Acute intestinal pseudo-obstruction (Ogilvie's syndrome) | journal = Clinics in Colon and Rectal Surgery | volume = 18 | issue = 2 | pages = 96–101 | date = May 2005 | pmid = 20011348 | pmc = 2780141 | doi = 10.1055/s-2005-870890 }}</ref>

Neostigmine is often prescribed for underactive urinary bladder.<ref>{{cite journal | vauthors = Moro C, Phelps C, Veer V, Clark J, Glasziou P, Tikkinen KA, Scott AM | title = The effectiveness of parasympathomimetics for treating underactive bladder: A systematic review and meta-analysis | journal = Neurourology and Urodynamics | volume = 41 | issue = 1 | pages = 127–139 | date = January 2022 | pmid = 34816481 | doi = 10.1002/nau.24839 | s2cid = 244530010 | url = https://pure.bond.edu.au/ws/files/118955227/AM_The_effectiveness_of_parasympathomimetics_for_treating.pdf }}</ref>

Hospitals sometimes administer a solution containing neostigmine intravenously to delay the effects of [[envenomation]] through [[snakebite]].<ref>{{cite web | vauthors = Franklin D | url = https://www.npr.org/blogs/health/2013/07/30/207050435/potential-treatment-for-snakebites-leads-to-a-paralyzing-test | title = Potential Treatment For Snakebites Leads To A Paralyzing Test | work = NPR | archive-url = https://web.archive.org/web/20140809234546/http://www.npr.org/blogs/health/2013/07/30/207050435/potential-treatment-for-snakebites-leads-to-a-paralyzing-test | archive-date= 9 August 2014 | date = 31 July 2013 }}</ref> Some promising research results have also been reported for administering the drug nasally in order to buy time if anti-venom is not immediately available.<ref name="pmid30154870">{{cite journal | vauthors = Bulfone TC, Samuel SP, Bickler PE, Lewin MR | title = Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite | journal = Journal of Tropical Medicine | volume = 2018 | pages = 4320175 | date = 2018 | pmid = 30154870 | pmc = 6091453 | doi = 10.1155/2018/4320175 | doi-access = free }}</ref>