Editing Notch signaling pathway (section)

== Discovery ==

In 1914, John S. Dexter noticed the appearance of a notch in the wings of the fruit fly ''[[Drosophila melanogaster]]''. The [[alleles]] of the gene were identified in 1917 by American evolutionary biologist [[Thomas Hunt Morgan]].<ref name=Morgan1917>{{Cite journal | vauthors = Morgan TH | author-link = Thomas Hunt Morgan | year = 1917 | title = The theory of the gene | journal = [[The American Naturalist]] | volume=51 | issue=609  | pages = 513–544 | doi=10.1086/279629 | bibcode = 1917ANat...51..513M | s2cid = 84050307 | url = https://zenodo.org/record/1431357 }}</ref><ref>{{cite book | vauthors = Morgan TH | title = The theory of the gene | edition = revised | publisher = Yale University Press | year = 1928 | pages = 77–81 | url = http://onlinebooks.library.upenn.edu/webbin/book/lookupid?key=olbp24097 | isbn = 978-0-8240-1384-4 }}</ref> Its molecular analysis and sequencing was independently undertaken in the 1980s by [[Spyros Artavanis-Tsakonas]] and [[Michael W. Young]].<ref name="pmid3935325">{{cite journal | vauthors = Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S | title = Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats | journal = Cell | volume = 43 | issue = 3 Pt 2 | pages = 567–581 | date = December 1985 | pmid = 3935325 | doi = 10.1016/0092-8674(85)90229-6 | doi-access = free }}</ref><ref name="pmid3097517">{{cite journal | vauthors = Kidd S, Kelley MR, Young MW | title = Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors | journal = Molecular and Cellular Biology | volume = 6 | issue = 9 | pages = 3094–3108 | date = September 1986 | pmid = 3097517 | pmc = 367044 | doi = 10.1128/mcb.6.9.3094 }}</ref> Alleles of the two ''[[Caenorhabditis elegans|C. elegans]]'' ''Notch'' genes were identified based on developmental phenotypes: ''lin-12''<ref>{{cite journal | vauthors = Greenwald IS, Sternberg PW, Horvitz HR | title = The lin-12 locus specifies cell fates in Caenorhabditis elegans | journal = Cell | volume = 34 | issue = 2 | pages = 435–444 | date = September 1983 | pmid = 6616618 | doi = 10.1016/0092-8674(83)90377-x | s2cid = 40668388 }}</ref> and ''glp-1''.<ref name=pmid3677168>{{cite journal | vauthors = Austin J, Kimble J | title = glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans | journal = Cell | volume = 51 | issue = 4 | pages = 589–599 | date = November 1987 | pmid = 3677168 | doi = 10.1016/0092-8674(87)90128-0 | s2cid = 31484517 }}</ref><ref name=PMID3677169>{{cite journal | vauthors = Priess JR, Schnabel H, Schnabel R | title = The glp-1 locus and cellular interactions in early C. elegans embryos | journal = Cell | volume = 51 | issue = 4 | pages = 601–611 | date = November 1987 | pmid = 3677169 | doi = 10.1016/0092-8674(87)90129-2 | s2cid = 6282210 }}</ref> The cloning and partial sequence of ''lin-12'' was reported at the same time as ''Drosophila'' ''Notch'' by Iva Greenwald.<ref name=PMID3000611>{{cite journal | vauthors = Greenwald I | title = lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor | journal = Cell | volume = 43 | issue = 3 Pt 2 | pages = 583–590 | date = December 1985 | pmid = 3000611 | doi = 10.1016/0092-8674(85)90230-2 | doi-access = free }}</ref>