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Paraventricular nucleus
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== Location == The paraventricular nucleus lies adjacent to the [[third ventricle]]. It lies within the periventricular zone and is not to be confused with the [[periventricular nucleus]], which occupies a more medial position, beneath the [[third ventricle]]. The PVN is highly vascularised and is protected by the [[blood–brain barrier]], although its [[neuroendocrine cells]] extend to sites (in the [[median eminence]] and in the [[posterior pituitary]]) beyond the blood–brain barrier.{{cn|date=May 2022}} PVN is accounting for only about 1% of the brain volume.In the rat, the PVN consists of approximately 100,000 neurons located in a volume of about 0.5 cubic millimetre.<ref>{{Cite journal |last1=Grassi |first1=D. |last2=Marraudino |first2=M. |last3=Garcia-Segura |first3=L. M. |last4=Panzica |first4=G. C. |date=2022-04-01 |title=The hypothalamic paraventricular nucleus as a central hub for the estrogenic modulation of neuroendocrine function and behavior |url=https://www.sciencedirect.com/science/article/pii/S0091302221000765 |journal=Frontiers in Neuroendocrinology |volume=65 |pages=100974 |doi=10.1016/j.yfrne.2021.100974 |pmid=34995643 |issn=0091-3022|url-access=subscription }}</ref>
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