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Peroxisome proliferator-activated receptor
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== Nomenclature and tissue distribution == {{infobox protein | Name = [[Peroxisome proliferator-activated receptor alpha]] | caption = | image = | width = | HGNCid = 9232 | Symbol = PPARA | AltSymbols = PPAR | EntrezGene = 5465 | OMIM = 170998 | RefSeq = NM_001001928 | UniProt = Q07869 | PDB = | ECnumber = | Chromosome = 22 | Arm = q | Band = 12 | LocusSupplementaryData = -q13.1 }} {{infobox protein | Name = [[Peroxisome proliferator-activated receptor gamma]] | caption = | image = PPARg.png | width = | HGNCid = 9236 | Symbol = PPARG | AltSymbols = | EntrezGene = 5468 | OMIM = 601487 | RefSeq = NM_005037 | UniProt = P37231 | PDB = | ECnumber = | Chromosome = 3 | Arm = p | Band = 25 | LocusSupplementaryData = }} {{infobox protein | Name = [[Peroxisome proliferator-activated receptor delta]] | caption = | image = | width = | HGNCid = 9235 | Symbol = PPARD | AltSymbols = | EntrezGene = 5467 | OMIM = 600409 | RefSeq = NM_006238 | UniProt = Q03181 | PDB = | ECnumber = | Chromosome = 6 | Arm = p | Band = 21.2 | LocusSupplementaryData = }} Three types of PPARs have been identified: alpha, [[PPARG|gamma]], and delta (beta):<ref name="Berger_2002" /> * [[Peroxisome proliferator-activated receptor alpha|'''α''' (alpha)]] - expressed in [[liver]], [[kidney]], [[heart]], [[muscle]], [[adipose tissue]], and others<ref name="pmid22247890">{{cite journal |vauthors=Tyagi S, Gupta P, Saini AS, Kaushal C, Sharma S |title=The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases |journal=J Adv Pharm Technol Res |volume=2 |issue=4 |pages=236–40 |date=October 2011 |pmid=22247890 |pmc=3255347 |doi=10.4103/2231-4040.90879 |doi-access=free }}</ref> * [[Peroxisome proliferator-activated receptor delta|'''β/δ''' (beta/delta)]] - expressed in many tissues, especially in [[brain]], [[adipose tissue]], and [[skin]] * [[Peroxisome proliferator-activated receptor gamma|'''γ''' (gamma)]] - although transcribed by the same gene, this PPAR, by way of [[alternative splicing]], is expressed in three forms: ** γ1 - expressed in virtually all tissues, including [[heart]], [[muscle]], [[colon (anatomy)|colon]], [[kidney]], [[pancreas]], and [[spleen]] ** γ2 - expressed mainly in [[adipose tissue]]; it is 30 [[amino acid]]s longer than γ1 ** γ3 - expressed in [[macrophage]]s, [[colon (anatomy)|large intestine]], [[white adipose tissue]]
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