Editing Platelet-derived growth factor (section)

== Types and classification ==

There are five different [[isoform]]s of PDGF that activate cellular response through two different [[receptor (biochemistry)|receptors]]. Known [[ligand]]s include: PDGF-AA (''[[PDGFA]]''), -BB (''[[PDGFB]]''), -CC (''[[PDGFC]]''), and -DD (''[[PDGFD]]''), and -AB (a ''[[PDGFA]]'' and ''[[PDGFB]]'' [[Protein dimer|heterodimer]]'')''. The ligands interact with the two [[Receptor tyrosine kinase|tyrosine kinase receptor]] monomers, PDGFRα (''[[PDGFRA]]'') and -Rβ (''[[PDGFRB]]'').<ref>{{Cite journal|last1=Fredriksson|first1=Linda|last2=Li|first2=Hong|last3=Eriksson|first3=Ulf|date=August 2004|title=The PDGF family: four gene products form five dimeric isoforms|journal=Cytokine & Growth Factor Reviews|volume=15|issue=4|pages=197–204|doi=10.1016/j.cytogfr.2004.03.007|pmid=15207811}}</ref> The PDGF family also includes a few other members of the family, including the [[VEGF sub-family]].<ref>{{Cite journal|last1=Tischer|first1=Edmund|last2=Gospodarowicz|first2=Denis|last3=Mitchell|first3=Richard|last4=Silva|first4=Maria|last5=Schilling|first5=James|last6=Lau|first6=Kenneth|last7=Crisp|first7=Tracey|last8=Fiddes|first8=John C.|last9=Abraham|first9=Judith A.|date=December 1989|title=Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family|journal=Biochemical and Biophysical Research Communications|volume=165|issue=3|pages=1198–1206|doi=10.1016/0006-291X(89)92729-0|pmid=2610687}}</ref>