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Primary familial brain calcification
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==Signs and symptoms== Symptoms of this disease include deterioration of motor functions and speech, seizures, and other involuntary movement. Other symptoms are headaches, dementia, and vision impairment. Characteristics of Parkinson's Disease are also similar to PFBC.<ref>{{cite web|title=NINDS Fahr's Syndrome Information Page|url=http://www.ninds.nih.gov/disorders/fahrs/fahrs.htm|publisher=National Institute of Neurological Disorders and Stroke|access-date=13 January 2007|archive-url=https://web.archive.org/web/20070205071541/http://www.ninds.nih.gov/disorders/fahrs/fahrs.htm|archive-date=5 February 2007|url-status=dead}}</ref> The disease usually manifests itself in the third to fifth decade of life but may appear in childhood or later in life.<ref name=Sobrido2007>Sobrido MJ, Hopfer S, Geschwind DH (2007) "[https://www.ncbi.nlm.nih.gov/books/NBK1421/ Familial idiopathic basal ganglia calcification]." In: Pagon RA, Bird TD, Dolan CR, Stephens K, editors. SourceGeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993β2004</ref> It usually presents with clumsiness, fatigability, unsteady gait, slow or slurred speech, [[dysphagia|difficulty swallowing]], involuntary movements or [[muscle cramp]]ing. [[Seizures]] of various types are common. Neuropsychiatric symptoms, which may be the first or the most prominent manifestations, range from mild difficulty with concentration and memory to changes in personality and/or behavior, to psychosis and dementia.<ref name=Chiu1993>{{cite journal |author1=Chiu HF| author2=Lam LC| author3=Shum PP | author4=Li KW |title=Idiopathic calcification of the basal ganglia |journal=Postgrad Med J |volume=69 |issue=807 |pages=68β70 |date=January 1993 |pmid=8446558 |pmc=2399589 |doi=10.1136/pgmj.69.807.68}}</ref>
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