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Prion
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== Etymology and pronunciation == The word ''prion'', coined in 1982 by [[Stanley B. Prusiner]], is derived from '''pr'''otein and infect'''ion''', hence '''prion''',<ref name="Prusiner82" /> and is short for "proteinaceous infectious particle",<ref name=pmid26324905>{{cite journal | vauthors = Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K | title = Evidence for Ξ±-synuclein prions causing multiple system atrophy in humans with parkinsonism | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 112 | issue = 38 | pages = E5308β17 | date = September 2015 | pmid = 26324905 | pmc = 4586853 | doi = 10.1073/pnas.1514475112 | doi-access = free | bibcode = 2015PNAS..112E5308P }}<br />Lay summary: {{cite web | vauthors = Makin S |title=A Red Flag for a Neurodegenerative Disease That May Be Transmissible |url=http://www.scientificamerican.com/article/a-red-flag-for-a-neurodegenerative-disease-that-may-be-transmissible/ |date=September 1, 2015 |website=Scientific American}}</ref> in reference to its ability to self-propagate and transmit its conformation to other proteins.<ref name="Nobel">{{cite web |title=Stanley B. Prusiner β Autobiography |url=http://nobelprize.org/nobel_prizes/medicine/laureates/1997/prusiner-autobio.html |publisher=NobelPrize.org |access-date=2007-01-02 |archive-date=2013-06-16 |archive-url=https://web.archive.org/web/20130616122714/http://www.nobelprize.org/nobel_prizes/medicine/laureates/1997/prusiner-autobio.html |url-status=live}}</ref> Its main pronunciation is {{IPAc-en|audio=Pronunciation prion.ogg|Λ|p|r|iΛ|Ι|n}},<ref>{{cite journal | vauthors = Schonberger LB, Schonberger RB | title = Etymologia: prion | journal = Emerging Infectious Diseases | volume = 18 | issue = 6 | pages = 1030β1 | date = June 2012 | pmid = 22607731 | pmc = 3381685 | doi = 10.3201/eid1806.120271 }}</ref><ref name="Dorlands">{{cite web |title=Dorland's Illustrated Medical Dictionary |publisher=Elsevier |url=http://dorlands.com/ |access-date=2016-07-22 |url-access=subscription |url-status=dead |archive-date=2014-01-11 |archive-url=https://web.archive.org/web/20140111192614/http://dorlands.com/}}</ref><ref name="MWU">{{cite web |title=Merriam-Webster's Unabridged Dictionary |publisher=Merriam-Webster |url=http://unabridged.merriam-webster.com/unabridged/ |access-date=2016-07-22 |archive-date=2020-05-25 |archive-url=https://web.archive.org/web/20200525084504/https://unabridged.merriam-webster.com/subscriber/login?redirect_to=%2Funabridged%2F |url-status=dead |url-access=subscription}}</ref> although {{IPAc-en|Λ|p|r|aΙͺ|Ι|n}}, as the [[homograph]]ic name of [[prion (bird)|the bird]] (prions or whalebirds) is pronounced,<ref name="MWU"/> is also heard.<ref name="AHD">{{cite web |title=The American Heritage Dictionary of the English Language |publisher=Houghton Mifflin Harcourt |url=https://ahdictionary.com/ |access-date=2016-07-22 |url-status=dead |archive-date=2015-09-25 |archive-url=https://web.archive.org/web/20150925104737/https://ahdictionary.com/}}</ref> In his 1982 paper introducing the term, Prusiner specified that it is "pronounced ''pree-on''".<ref name=Prusiner82/>
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