Editing Procainamide (section)

==Uses==
===Medical===
Procainamide is used for treating ventricular [[arrhythmias]]: ventricular [[ectopia (medicine)|ectopy]] and [[tachycardia]] and supraventricular arrhythmias: [[atrial fibrillation]], and re-entrant and automatic supraventricular tachycardia.<ref name=Gould>{{cite book | veditors = Gould LA |title=Drug Treatment of Cardiac Arrhythmias |date=1983 |publisher=Futura Publishing Company |location=Mount Kisco |isbn=0879931906 |pages=73–74}}</ref> For example, it can be used to convert new-onset [[atrial fibrillation]], and although was initially thought to be suboptimal for this purpose, a growing body of literature is amounting in support for this exact cause.<ref>{{cite journal | vauthors = Stiell IG, Sivilotti ML, Taljaard M, Birnie D, Vadeboncoeur A, Hohl CM, McRae AD, Rowe BH, Brison RJ, Thiruganasambandamoorthy V, Macle L, Borgundvaag B, Morris J, Mercier E, Clement CM, Brinkhurst J, Sheehan C, Brown E, Nemnom MJ, Wells GA, Perry JJ | title = Electrical versus pharmacological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial | journal = Lancet | volume = 395 | issue = 10221 | pages = 339–349 | date = February 2020 | pmid = 32007169 | doi = 10.1016/S0140-6736(19)32994-0 | s2cid = 210978499 }}</ref><ref>{{cite journal | vauthors = Fenster PE, Comess KA, Marsh R, Katzenberg C, Hager WD | title = Conversion of atrial fibrillation to sinus rhythm by acute intravenous procainamide infusion | journal = American Heart Journal | volume = 106 | issue = 3 | pages = 501–504 | date = September 1983 | pmid = 6881022 | doi = 10.1016/0002-8703(83)90692-0 }}</ref>

It is administered by mouth, by intramuscular injection, or intravenously.<ref name="ten">{{cite journal | vauthors = Koch-Weser J, Klein SW | title = Procainamide dosage schedules, plasma concentrations, and clinical effects | journal = JAMA | volume = 215 | issue = 9 | pages = 1454–1460 | date = March 1971 | pmid = 5107621 | doi = 10.1001/jama.1971.03180220036006 }}</ref><ref>{{cite book | veditors = Antman EM, Sabatine MS |title=Cardiovascular Therapeutics: A companion to Braunwald's heart disease |page=410 |date=2013 |publisher=Elsevier/Saunders |location=Philadelphia, PA |isbn=978-1-4557-0101-8 |edition=4th}}</ref>

===Others===
It has also been used as a [[chromatography]] resin because it somewhat binds protein.<ref>{{cite web| title=Procainamide Sepharose 4 Fast Flow| website=GE Healthcare Life Sciences| url=http://www.gelifesciences.com/webapp/wcs/stores/servlet/catalog/en/GELifeSciences-cz/products/AlternativeProductStructure_17319/28411101| access-date=2017-07-24| archive-date=2021-08-29| archive-url=https://web.archive.org/web/20210829162220/https://www.cytivalifesciences.com/country-selection?originalItemPath=%2fshop%2fchromatography%2fresins%2faffinity-specific-groups%2fprocainamide-sepharose-4-fast-flow-p-03714| url-status=dead}}</ref><ref>{{cite journal | vauthors = De la Hoz D, Doctor BP, Ralston JS, Rush RS, Wolfe AD | title = A simplified procedure for the purification of large quantities of fetal bovine serum acetylcholinesterase | journal = Life Sciences | volume = 39 | issue = 3 | pages = 195–199 | date = July 1986 | pmid = 3736320 | doi = 10.1016/0024-3205(86)90530-8 }}</ref><ref>{{cite journal | vauthors = Ralston JS, Main AR, Kilpatrick BF, Chasson AL | title = Use of procainamide gels in the purification of human and horse serum cholinesterases | journal = The Biochemical Journal | volume = 211 | issue = 1 | pages = 243–250 | date = April 1983 | pmid = 6870822 | pmc = 1154348 | doi = 10.1042/bj2110243 }}</ref><ref>{{cite journal | vauthors = Saxena A, Luo C, Doctor BP | title = Developing procedures for the large-scale purification of human serum butyrylcholinesterase | journal = Protein Expression and Purification | volume = 61 | issue = 2 | pages = 191–196 | date = October 2008 | pmid = 18602477 | doi = 10.1016/j.pep.2008.05.021 }}</ref>