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Prochlorperazine
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== Medical uses == ===Vomiting=== Prochlorperazine is used to [[antiemetic|prevent vomiting]] caused by [[chemotherapy]], [[radiation therapy]] and [[Postoperative nausea and vomiting|in the pre- and postoperative setting]].<ref name=Lin2016>{{cite journal | vauthors = Lau Moon Lin M, Robinson PD, Flank J, Sung L, Dupuis LL | title = The Safety of Prochlorperazine in Children: A Systematic Review and Meta-Analysis | journal = Drug Safety | volume = 39 | issue = 6 | pages = 509β516 | date = June 2016 | pmid = 26884326 | doi = 10.1007/s40264-016-0398-9 | s2cid = 39349233 }}</ref> A 2015 Cochrane review found no differences in efficacy among drugs commonly used for this purpose in emergency rooms.<ref>{{cite journal | vauthors = Furyk JS, Meek RA, Egerton-Warburton D | title = Drugs for the treatment of nausea and vomiting in adults in the emergency department setting | journal = The Cochrane Database of Systematic Reviews | issue = 9 | pages = CD010106 | date = September 2015 | volume = 2018 | pmid = 26411330 | pmc = 6517141 | doi = 10.1002/14651858.CD010106.pub2 }}</ref> ===Migraine=== Prochlorperazine, generally by intravenous, is used to treat [[migraine]].<ref name="somestats">{{cite journal | vauthors = Golikhatir I, Cheraghmakani H, Bozorgi F, Jahanian F, Sazgar M, Montazer SH | title = The Efficacy and Safety of Prochlorperazine in Patients With Acute Migraine: A Systematic Review and Meta-Analysis | journal = Headache | volume = 59 | issue = 5 | pages = 682β700 | date = May 2019 | pmid = 30990883 | doi = 10.1111/head.13527 | s2cid = 119544256 }}</ref><ref>{{cite journal | vauthors = Patniyot IR, Gelfand AA | title = Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review | journal = Headache | volume = 56 | issue = 1 | pages = 49β70 | date = January 2016 | pmid = 26790849 | doi = 10.1111/head.12746 | s2cid = 25893066 }}</ref> Such use is recommended by The American Headache Society.<ref name=AHS2016/> A 2019 systematic review found prochlorperazine was nearly three times more likely than [[metoclopramide]] to relieve headache within 60 minutes of administration.<ref name="somestats"/> ===Labyrinthitis=== In the UK prochlorperazine maleate has been used for [[labyrinthitis]], which includes nausea and [[vertigo]].<ref>{{cite journal | vauthors = Coatesworth AP | title = Assessment and treatment of dizziness | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 69 | issue = 5 | pages = 706β707 | date = November 2000 | pmid = 11184241 | pmc = 1763384 | doi = 10.1136/jnnp.69.5.706 }}</ref>
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