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Protein complex
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== Function == [[Image:Barnase-barstar-1brs.png|thumb|right|250px|The ''[[Bacillus amyloliquefaciens]]'' [[ribonuclease]] [[barnase]] (colored) and its [[enzyme inhibitor|inhibitor]] (blue) in a complex]] Protein complex formation can activate or inhibit one or more of the complex members and in this way, protein complex formation can be similar to [[phosphorylation]]. Individual proteins can participate in a variety of protein complexes. Different complexes perform different functions, and the same complex can perform multiple functions depending on various factors. Factors include: * Cell compartment location * Cell cycle stage * Cell nutritional status{{citation needed|date=April 2019}} Many protein complexes are well understood, particularly in the [[model organism]] ''[[Saccharomyces cerevisiae]]'' (yeast). For this relatively simple organism, the study of protein complexes is now [[genome]] wide and the elucidation of most of its protein complexes is ongoing.{{citation needed|date=June 2019}} In 2021, researchers used [[deep learning]] software [[Rosetta@home#RoseTTAFold|RoseTTAFold]] along with [[AlphaFold]] to solve the structures of 712 [[eukaryote]] complexes. They compared 6000 yeast proteins to those from 2026 other fungi and 4325 other eukaryotes.<ref>{{Cite web|title=AI cracks the code of protein complexes—providing a road map for new drug targets|url=https://www.science.org/content/article/ai-cracks-code-protein-complexes-providing-road-map-new-drug-targets|access-date=2021-11-14|website=www.science.org|language=en}}</ref>
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