Editing Psilocin (section)

==Uses==
[[File:Dried Cubensis.jpg|thumb|left|Dried [[psilocybin mushroom]]s. (Notice the characteristic blue bruising by the stems of the mushrooms.)]]

Psilocin is used [[recreational drug|recreationally]], [[spirituality|spirituality]] or [[shamanism|shamanically]], and [[medicine|medically]]. It is most commonly used in the form of its [[prodrug]]s such as [[psilocybin]] and [[4-AcO-DMT]] (psilacetin). However, psilocin may also be used itself, either in the form of [[psilocybin-containing mushroom]]s (which variably contain psilocin up to similar amounts as psilocybin) or in [[chemical synthesis|synthetic]] form.

Psilocin is usually used [[oral administration|orally]], but may also be taken [[intravenous injection|intravenously]]. In terms of [[Dosage (pharmacology)|dosage]], it is slightly more [[potency (pharmacology)|potent]] than psilocybin, about 1.4-fold so (i.e., 1.4{{nbsp}}mg psilocybin equals about 1.0{{nbsp}}mg psilocin).<ref name="TylšPáleníčekHoráček2014" /><ref name="Hofmann1968">{{cite book | author = [[Albert Hofmann]] | chapter = Psychotomimetic Agents | pages = 169–235 | veditors = Burger A | title = Drugs Affecting the Central Nervous System | volume = 2 | date = 1968 | publisher = M. Dekker | location = New York | oclc = 245452885 | ol = OL13539506M | chapter-url = https://archive.org/details/drugsaffectingce0000edit/page/169/mode/1up | url = https://books.google.com/books?id=o_GMwgEACAAJ | quote = Psilocin is approximately 1.4 times as potent as psilocybin. This ratio is the same as that of the molecular weights of the two drugs.}}</ref><ref name="WolbachMinerIsbell1962">{{cite journal | vauthors = Wolbach AB, Miner EJ, Isbell H | title = Comparison of psilocin with psilocybin, mescaline and LSD-25 | journal = Psychopharmacologia | volume = 3 | issue = 3| pages = 219–223 | date = 1962 | pmid = 14007905 | doi = 10.1007/BF00412109 | url = | quote = Psilocin is approximately 1.4 times as potent as psilocybin. This ratio is the same as that of the molecular weights of the two drugs.}}</ref> This is related to psilocin's lack of [[ester]] [[prodrug]] [[moiety (chemistry)|moiety]], which results in its [[molecular weight]] being about 40% lower than that of psilocybin (204.273{{nbsp}}g/mol and 284.252{{nbsp}}g/mol, respectively).<ref name="Hofmann1968" /><ref name="WolbachMinerIsbell1962" /> The human dosage of psilocin has been given as 10 to 20{{nbsp}}mg.<ref name="Nichols2004">{{cite journal | vauthors = Nichols DE | title = Hallucinogens | journal = Pharmacol Ther | volume = 101 | issue = 2 | pages = 131–181 | date = February 2004 | pmid = 14761703 | doi = 10.1016/j.pharmthera.2003.11.002 | url = }}</ref><ref name="FantegrossiMurnaneReissig2008">{{cite journal | vauthors = Fantegrossi WE, Murnane KS, Reissig CJ | title = The behavioral pharmacology of hallucinogens | journal = Biochem Pharmacol | volume = 75 | issue = 1 | pages = 17–33 | date = January 2008 | pmid = 17977517 | pmc = 2247373 | doi = 10.1016/j.bcp.2007.07.018 | url = https://www.iceers.org/Documents_ICEERS_site/Scientific_Papers/ayahuasca/Fantegrossi%20et%20al_2008_Behavioral_Pharm_Hallucinogens.pdf}}</ref><ref name="Nichols2016">{{cite journal | vauthors = Nichols DE | title = Psychedelics | journal = Pharmacol Rev | volume = 68 | issue = 2 | pages = 264–355 | date = April 2016 | pmid = 26841800 | pmc = 4813425 | doi = 10.1124/pr.115.011478 | url = https://pmc.ncbi.nlm.nih.gov/articles/PMC4813425/pdf/pr.115.011478.pdf}}</ref>