Editing Repolarization (section)

== Deviations from normal repolarization ==
Blockages in repolarization can arise due to modifications of the voltage-gated K<sup>+</sup> channels. This is demonstrated with selectively blocking voltage gated K<sup>+</sup> channels with the antagonist [[tetraethylammonium]] (TEA). By blocking the channel, repolarization is effectively stopped.<ref>{{cite book | vauthors = Whishaw IQ, Kolb B | date = 2015 | title = Fundamentals of Human Neuropsychology | location = New York, NY | publisher = Worth Publishers }}</ref> [[Dendrotoxin]]s are another example of a selective pharmacological blocker for voltage gated K<sup>+</sup> channels. The lack of repolarization means that neuron stays at a high voltage, which slows sodium channel deactivation to a point where there is not enough inwards Na<sup>+</sup> current to depolarize and sustain firing.<ref>{{cite book | vauthors = Hirokawa N, Windhorst U | date = 2008 | chapter = Depolarization Block | title = Encyclopedia of Neuroscience | pages = 943–944 | doi = 10.1007/978-3-540-29678-2_1453 | isbn = 978-3-540-23735-8 }}</ref>