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Retinoid
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==Types== Retinoids are divided into four generations based on their molecular structure and receptor selectivity.<ref>{{cite journal | vauthors=Motamedi M, Chehade A, Sanghera R, Grewal P | title=A Clinician's Guide to Topical Retinoids | journal=Journal of Cutaneous Medicine and Surgery | volume=26 | issue=1 | pages=71β78 | date=2021-07-22 | pmid=34292058 | pmc=8750127 | doi=10.1177/12034754211035091 | publisher=SAGE Publications }}</ref> {| class="wikitable" |- ! Generation !! Description !! Compounds |- | First generation || Isomers and naturally occurring compounds || [[retinol]], [[retinal]], [[tretinoin]] ([[retinoic acid]]), [[isotretinoin]], and [[alitretinoin]] |- | Second generation || Synthetic analogs formulated for oral dosing. There are no topically available second generation formulations of retinoids. || [[etretinate]] and its metabolite [[acitretin]] |- | Third generation || Retinoidal benzoic acid derivatives || [[adapalene]], [[oleyl adapalenate]], [[bexarotene]], and [[tazarotene]] |- | Fourth generation || Topical retinoid with selectivity towards the RAR receptor located in the epidermis || [[Trifarotene]], [[seletinoid G]] |- |}
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