Editing Rossmann fold (section)

== History ==
The Rossmann fold was first described by Dr. [[Michael Rossmann]] and coworkers in 1974.<ref name="Kessel_2010" /> He was the first to deduce the structure of lactate dehydrogenase and characterized the structural motif within this enzyme which would later be called the Rossmann fold. It was subsequently found that most dehydrogenases that utilize NAD or NADP contain this same structurally conserved Rossmann fold motif.<ref name="Kessel_2010">{{cite book | title = Introduction to Proteins: Structure, Function, and Motion | vauthors = Kessel A | publisher = CRC Press | year = 2010 | isbn = 978-1-4398-1071-2 | location = Florida | pages = 143 }}</ref><ref>{{cite journal | vauthors = Rao ST, Rossmann MG | title = Comparison of super-secondary structures in proteins | journal = Journal of Molecular Biology | volume = 76 | issue = 2 | pages = 241–56 | date = May 1973 | pmid = 4737475 | doi = 10.1016/0022-2836(73)90388-4 }}</ref>

In 1989, [[Israel Hanukoglu]] from the [[Weizmann Institute of Science]] discovered that the consensus sequence for NADP<sup>+</sup> binding site in some enzymes that utilize NADP<sup>+</sup> differs from the NAD<sup>+</sup> binding motif.<ref name="Hanukoglu_1989">{{cite journal | vauthors = Hanukoglu I, Gutfinger T | title = cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases | journal = European Journal of Biochemistry | volume = 180 | issue = 2 | pages = 479–84 | date = March 1989 | pmid = 2924777 | doi = 10.1111/j.1432-1033.1989.tb14671.x | url = https://zenodo.org/record/890733 | doi-access = free }}</ref> This discovery was used to re-engineer coenzyme specificities of enzymes.<ref name="Scrutton_1990">{{cite journal | vauthors = Scrutton NS, Berry A, Perham RN | title = Redesign of the coenzyme specificity of a dehydrogenase by protein engineering | journal = Nature | volume = 343 | issue = 6253 | pages = 38–43 | date = January 1990 | pmid = 2296288 | doi = 10.1038/343038a0 | bibcode = 1990Natur.343...38S | s2cid = 1580419 }}</ref>