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SH3 domain
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==Structure== The SH3 domain has a characteristic [[beta-barrel]] fold that consists of five or six [[beta strand|Ξ²-strands]] arranged as two tightly packed [[anti-parallel Ξ² sheet]]s. The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes.<ref name="pmid10322416">{{cite journal | vauthors = Whisstock JC, Lesk AM | title = SH3 domains in prokaryotes | journal = Trends in Biochemical Sciences | volume = 24 | issue = 4 | pages = 132β3 | date = April 1999 | pmid = 10322416 | doi = 10.1016/s0968-0004(99)01366-3 }}</ref>
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