Editing SOS response (section)

==Discovery==

The SOS response was articulated by [[Evelyn Witkin]].<ref name="Fitzgerald">{{cite journal |last1=Fitzgerald |first1=Devon M. |last2=Hastings |first2=P.J. |last3=Rosenberg |first3=Susan M. |title=Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance |journal=Annual Review of Cancer Biology |date=6 March 2017 |volume=1 |issue=1 |pages=119–140 |doi=10.1146/annurev-cancerbio-050216-121919 |pmid=29399660 |pmc=5794033 |url=https://doi.org/10.1146/annurev-cancerbio-050216-121919 |access-date=6 March 2023 }}</ref><ref>{{cite journal |last1=Witkin |first1=E M |title=The radiation sensitivity of Escherichia coli B: a hypothesis relating filament formation and prophage induction. |journal=Proceedings of the National Academy of Sciences |date=May 1967 |volume=57 |issue=5 |pages=1275–9 |doi=10.1073/pnas.57.5.1275 |pmid=5341236 |pmc=224468 |bibcode=1967PNAS...57.1275W |doi-access=free}}</ref> Later, by characterizing the phenotypes of mutagenised ''E. coli'', she and post doctoral student [[Miroslav Radman]] detailed the SOS response to UV radiation in bacteria.<ref name="Fitzgerald"/><ref>{{Cite journal |last1=Witkin |first1=E. M. |author-link1=Evelyn M. Witkin |title=Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli |journal=Bacteriological Reviews |volume=40 |issue=4 |pages=869–907 |year=1976 |doi =10.1128/MMBR.40.4.869-907.1976 |pmid=795416 |pmc=413988}}</ref> The SOS response to DNA damage was a seminal discovery because it was the first coordinated stress response to be elucidated.<ref>{{cite journal |title=Phenomenology of an inducible mutagenic DNA repair pathway in ''Escherichia coli'': SOS repair hypothesis |last=Radman |first=M |journal=Basic Life Sciences |year=1975 |volume=5A |pages=355–367 |doi=10.1007/978-1-4684-2895-7_48 |pmid=1103845}}</ref>