Editing Sup35p (section)

== History ==
Sup35p was shown to propagate in a [[prion]] form in 1994 by [[Reed Wickner]]. For this reason it is an intensely studied protein. When yeast cells harbor Sup35p in the prion state the resulting phenotype is known as [PSI+]. In [PSI+] cells Sup35p exists in an [[amyloid]] state that can be propagated and passed to daughter cells. This results in less soluble and functional protein and thus in an increased rate of nonsense suppression (translational read-through of stop codons).

The overexpression of the gene has been shown to induce the [Psi+] conformation.