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Total synthesis
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==Scope and definitions== There are numerous classes of natural products for which total synthesis is applied to. These include (but are not limited to): [[terpenes]], [[alkaloids]],<ref>{{cite journal | last1 = Eichberg | first1 = Michael J. | last2 = Dorta | first2 = Rosa L. | last3 = Grotjahn | first3 = Douglas B. | last4 = Lamottke | first4 = Kai | last5 = Schmidt | first5 = Martin | last6 = Vollhardt | first6 = K. Peter C. | year = 2001 | title = Approaches to the Synthesis of (±)-Strychnine via the Cobalt-Mediated [2 + 2 + 2] Cycloaddition: Rapid Assembly of a Classic Framework | journal = [[J. Am. Chem. Soc.]] | volume = 123 | issue = 38| pages = 9324–9337 | doi = 10.1021/ja016333t | pmid = 11562215 | bibcode = 2001JAChS.123.9324E }}</ref> [[polyketides]].<ref>{{citation|author=Michael Müller, Kai Lamottke, Erich Löw, Eva Magor-Veenstra, Wolfgang Steglich |date=2001 |issue=15 |pages=2483-2489. https://doi.org/10.1039/B003053H |periodical=Journal of the Chemical Society, Perkin Transactions 1 |title=Stereoselective total syntheses of atrochrysone, torosachrysone and related 3, 4-dihydroanthracen-1 (2 H)-ones|doi=10.1039/B003053H }}<!-- auto-translated from German by Module:CS1 translator --></ref><ref>{{citation|author=Guido François, Tania Steenackers, Laurent Aké Assi, Wolfgang Steglich, Kai Lamottke, Jörg Holenz, Gerhard Bringmann |date=1999 |issue=7 |pages=582–588 https://doi.org/10.1007/s004360050598 |periodical=Parasitology Research |pmid=10382608 |title=Vismione H and structurally related anthranoid compounds of natural and synthetic origin as promising drugs against the human malaria parasite Plasmodium falciparum: structure-activity relationships |volume=85|doi=10.1007/s004360050598 }}<!-- auto-translated from German by Module:CS1 translator --></ref> and [[polyethers]].<ref name="Natural Products">{{cite book | vauthors = Springob K |title=Plant-derived Natural Products |date=1 June 2009 |publisher=Springer |isbn=978-0-387-85498-4 |pages=3–50 |doi=10.1007/978-0-387-85498-4_1 |url=https://link.springer.com/chapter/10.1007/978-0-387-85498-4_1 |access-date=24 June 2021}}</ref> Total synthesis targets are sometimes referred to by their organismal origin such as plant, marine, and fungal.<ref name=Lamottke/> The term total synthesis is less frequently but still accurately applied to the synthesis of natural [[polypeptide]]s and [[polynucleotide]]s. The peptide hormones [[oxytocin]] and [[vasopressin]] were isolated and their total syntheses first reported in 1954.<ref>{{cite journal|title = The Synthesis of Oxytocin| vauthors = du Vigneaud V, Ressler C, Swan JM, Roberts CW, Katsoyannis PG |journal = [[Journal of the American Chemical Society]]|volume = 76|issue = 12|pages = 3115–3121|year = 1954|doi = 10.1021/ja01641a004| bibcode = 1954JAChS..76.3115D }}</ref> It is not uncommon for natural product targets to feature multiple structural components of several natural product classes.
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