Editing Tryptamine (section)

== Natural occurrences ==
''For a list of plants, fungi and animals containing tryptamines, see [[List of psychoactive plants]] and [[List of naturally occurring tryptamines]].''

=== Mammalian brain ===
Endogenous levels of tryptamine in the mammalian brain are less than 100&nbsp;ng per gram of tissue.<ref name=":03"/><ref name="BerryGainetdinovHoener2017" /> However, elevated levels of trace amines have been observed in patients with certain neuropsychiatric disorders taking medications, such as [[Bipolar disorder|bipolar depression]] and [[schizophrenia]].<ref name="Miller2011">{{Cite journal|last=Miller|first=Gregory M.|date=2011|title=The Emerging Role of Trace Amine Associated Receptor 1 in the Functional Regulation of Monoamine Transporters and Dopaminergic Activity|journal=Journal of Neurochemistry|volume=116|issue=2|pages=164–176|doi=10.1111/j.1471-4159.2010.07109.x|issn=0022-3042|pmc=3005101|pmid=21073468}}</ref>

=== Mammalian gut microbiome ===
Tryptamine is relatively abundant in the [[digestive system|gut]] and feces of humans and rodents.<ref name=":32"/><ref name=":103"/> [[Commensalism|Commensal]] bacteria, including ''Ruminococcus gnavus'' and ''[[Clostridium sporogenes]]'' in the [[gastrointestinal tract]], possess the [[enzyme]] tryptophan [[Decarboxylation|decarboxylase]], which aids in the conversion of dietary tryptophan to tryptamine.<ref name=":32" /> Tryptamine is a [[ligand]] for gut epithelial serotonin type 4 (5-HT<sub>4</sub>) receptors and regulates gastrointestinal [[electrolyte]] balance through colonic secretions.<ref name=":103"/>