Editing Typical antipsychotic (section)

== Clinical uses ==
Typical antipsychotics block the [[Dopamine receptor D2|dopamine 2 receptor (D2)]] receptor, causing a tranquilizing effect.<ref name="Schatzberg 2019">{{cite book |title=Schatzberg's Manual of Clinical Psychopharmacology |date=2019 |publisher=American Psychiatric Association Publishing |isbn=978-1-61537-230-0 |edition=Ninth |url=https://www.appi.org/Products/Psychopharmacology/Schatzbergs-Manual-of-Clinical-Psychopharmacology |access-date=2020-06-21 |archive-date=2020-06-21 |archive-url=https://web.archive.org/web/20200621155952/https://www.appi.org/Products/Psychopharmacology/Schatzbergs-Manual-of-Clinical-Psychopharmacology |url-status=dead }}</ref> It is thought that 60–80% of D2 receptors need to be occupied for antipsychotic effect.<ref name="Schatzberg 2019" /> For reference, the typical antipsychotic [[haloperidol]] tends to block about 80% of D2 receptors at doses ranging from 2 to 5&nbsp;mg per day.<ref name="Schatzberg 2019" /> On the aggregate level, no typical antipsychotic is more effective than any other, though people will vary in which antipsychotic they prefer to take based on individual differences in tolerability and effectiveness.<ref name="Schatzberg 2019" /> Typical antipsychotics can be used to treat, e.g., schizophrenia or severe agitation.<ref name="Schatzberg 2019" /> Haloperidol, due to the availability of a rapid-acting injectable formulation and decades of use, remains the most commonly used antipsychotic for treating severe agitation in the emergency department setting.<ref name="Schatzberg 2019" />