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== History == In 1931, [[Germans|German]] [[Engineer|engineers]] [[Max Knoll]] and [[Ernst Ruska]] invented the first electron microscope.<ref>{{cite book |last=Masters |first=Barry R |date=March 2009 |chapter=History of the Electron Microscope in Cell Biology |title=Encyclopedia of Life Sciences (ELS) |publisher=John Wiley & Sons, Ltd |location=Chichester |doi=10.1002/9780470015902.a0021539 |isbn=9780470016176 |chapter-url=http://fen.bilkent.edu.tr/~physics/news/masters/ELS_HistoryEM.pdf}}</ref> With the development and invention of this microscope, the range of observable structures that were able to be explored and analyzed increased immensely, as biologists became progressively interested in the submicroscopic organization of cells. This new area of research concerned itself with substructure, also known as the ultrastructure.<ref>{{cite book | last=Brieger | first=E.M. | title=Structure and Ultrastructure of Microorganisms | chapter=Ultrastructure of the Cell | publisher=Elsevier | date=1963 | isbn=978-0-12-134350-7 | doi=10.1016/b978-0-12-134350-7.50005-8 | page=1β7}}</ref>
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