Editing Active site (section)

===Metal ions===
[[Metal ions in aqueous solution|Metal ions]] have multiple roles during the reaction. Firstly it can bind to negatively charged substrate groups so they will not repel electron pairs from active site's nucleophilic groups. It can attract negatively charged electrons to increase [[electrophilicity]]. It can also bridge between active site and substrate. At last, they may change the conformational structure of the substrate to favour reaction.
<ref name=":1" />{{Rp|158}}