Editing Alpha-synuclein (section)

== Protein-protein interactions ==

Alpha-synuclein has been shown to [[Protein-protein interaction|interact]] with
* [[Dopamine transporter]],<ref name="Wersinger_2003">{{cite journal | vauthors = Wersinger C, Sidhu A | title = Attenuation of dopamine transporter activity by alpha-synuclein | journal = Neuroscience Letters | volume = 340 | issue = 3 | pages = 189–192 | date = April 2003 | pmid = 12672538 | doi = 10.1016/S0304-3940(03)00097-1 | s2cid = 54381509 }}</ref><ref name="Lee_2001">{{cite journal | vauthors = Lee FJ, Liu F, Pristupa ZB, Niznik HB | title = Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis | journal = FASEB Journal| volume = 15 | issue = 6 | pages = 916–926 | date = April 2001 | pmid = 11292651 | doi = 10.1096/fj.00-0334com | doi-access = free | s2cid = 3406798 }}</ref>
* [[Parkin (ligase)]],<ref name="Choi_2001">{{cite journal | vauthors = Choi P, Golts N, Snyder H, Chong M, Petrucelli L, Hardy J, Sparkman D, Cochran E, Lee JM, Wolozin B | title = Co-association of parkin and alpha-synuclein | journal = NeuroReport | volume = 12 | issue = 13 | pages = 2839–2843 | date = September 2001 | pmid = 11588587 | doi = 10.1097/00001756-200109170-00017 | author10-link = Benjamin Wolozin | s2cid = 83941655 }}</ref><ref name="Kawahara_2008">{{cite journal | vauthors = Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E | title = alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease | journal = The Journal of Biological Chemistry | volume = 283 | issue = 11 | pages = 6979–6987 | date = March 2008 | pmid = 18195004 | doi = 10.1074/jbc.M710418200 | doi-access = free }}</ref>
* [[Phospholipase D1]],<ref name="Ahn_2002">{{cite journal | vauthors = Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Lee YH, Kwon TK, Chung KC, Yoon SH, Hahn SJ, Kim MS, Jo YH, Min DS | title = alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 14 | pages = 12334–12342 | date = April 2002 | pmid = 11821392 | doi = 10.1074/jbc.M110414200 | s2cid = 85695661 | doi-access = free }}</ref>
* [[SNCAIP]],<ref name="Neystat_2002">{{cite journal | vauthors = Neystat M, Rzhetskaya M, Kholodilov N, Burke RE | title = Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay | journal = Neuroscience Letters | volume = 325 | issue = 2 | pages = 119–123 | date = June 2002 | pmid = 12044636 | doi = 10.1016/S0304-3940(02)00253-7 | s2cid = 11517781 }}</ref><ref name="Reed_1991">{{cite journal | vauthors = Reed JC, Meister L, Tanaka S, Cuddy M, Yum S, Geyer C, Pleasure D | title = Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin | journal = Cancer Research | volume = 51 | issue = 24 | pages = 6529–6538 | date = December 1991 | pmid = 1742726 }}</ref><ref name="Kawamata_2001">{{cite journal | vauthors = Kawamata H, McLean PJ, Sharma N, Hyman BT | title = Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations | journal = Journal of Neurochemistry | volume = 77 | issue = 3 | pages = 929–934 | date = May 2001 | pmid = 11331421 | doi = 10.1046/j.1471-4159.2001.00301.x | s2cid = 83885937 | doi-access = free }}</ref><ref name="Engelender_1999">{{cite journal | vauthors = Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA | title = Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions | journal = Nature Genetics | volume = 22 | issue = 1 | pages = 110–114 | date = May 1999 | pmid = 10319874 | doi = 10.1038/8820 | author12-link = Ted M. Dawson | s2cid = 2611127 }}</ref>
* [[Tau protein]].<ref>{{cite journal | vauthors = Lee VM, Giasson BI, Trojanowski JQ | title = More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases | journal = Trends in Neurosciences | volume = 27 | issue = 3 | pages = 129–134 | date = March 2004 | pmid = 15036877 | doi = 10.1016/j.tins.2004.01.007 | s2cid = 9545889 }}</ref><ref name="Jensen_1999">{{cite journal | vauthors = Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R | title = alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 36 | pages = 25481–25489 | date = September 1999 | pmid = 10464279 | doi = 10.1074/jbc.274.36.25481 | s2cid = 23877061 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Giasson BI, Lee VM, Trojanowski JQ | title = Interactions of amyloidogenic proteins | journal = Neuromolecular Medicine | volume = 4 | issue = 1–2 | pages = 49–58 | year = 2003 | pmid = 14528052 | doi = 10.1385/NMM:4:1-2:49 | s2cid = 9086733 }}</ref>
* [[Beta amyloid]]<ref name="Ono_2012">{{cite journal | vauthors = Ono K, Takahashi R, Ikeda T, Yamada M | title = Cross-seeding effects of amyloid β-protein and α-synuclein | journal = Journal of Neurochemistry | volume = 122 | issue = 5 | pages = 883–890 | date = September 2012 | pmid = 22734715 | doi = 10.1111/j.1471-4159.2012.07847.x | s2cid = 17593306 | hdl = 2297/34736 | url = https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=13927&item_no=1&attribute_id=26&file_no=1 | doi-access = free }}</ref>