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Bayes' theorem
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====Sensitivity or specificity==== The importance of [[Specificity (tests)|specificity]] can be seen by showing that even if sensitivity is raised to 100% and specificity remains at 80%, the probability that someone who tests positive is a cannabis user rises only from 19% to 21%, but if the sensitivity is held at 90% and the specificity is increased to 95%, the probability rises to 49%. {| class="wikitable" style="display:inline-table;" ! {{diagonal split header|Actual|Test}} ! style="width:5ex;"|Positive ! style="width:5ex;"|Negative ! rowspan="5" style="padding:0;"| ! Total |- ! User | style="text-align:right" | '''45''' | style="text-align:right" | 5 | style="text-align:right" | 50 |- ! Non-user | style="text-align:right" | 190 | style="text-align:right" | 760 | style="text-align:right" | 950 |- | colspan="5" style="padding:0;"| |- ! Total | style="text-align:right" | '''235''' | style="text-align:right" | 765 | style="text-align:right" | 1000 |- | colspan="5" style="padding:0 0 1ex 0;border:none;background:transparent;"| 90% sensitive, 80% specific, PPV=45/235 ≈ 19% |} {| class="wikitable" style="display:inline-table;" ! {{diagonal split header|Actual|Test}} ! style="width:5ex;"|Positive ! style="width:5ex;"|Negative ! rowspan="5" style="padding:0;"| ! Total |- ! User | style="text-align:right" | '''50''' | style="text-align:right" | 0 | style="text-align:right" | 50 |- ! Non-user | style="text-align:right" | 190 | style="text-align:right" | 760 | style="text-align:right" | 950 |- | colspan="5" style="padding:0;"| |- ! Total | style="text-align:right" | '''240''' | style="text-align:right" | 760 | style="text-align:right" | 1000 |- | colspan="5" style="padding:0 0 1ex 0;border:none;background:transparent;"| 100% sensitive, 80% specific, PPV=50/240 ≈ 21% |} {| class="wikitable" style="display:inline-table;" ! {{diagonal split header|Actual|Test}} ! style="width:5ex;"|Positive ! style="width:5ex;"|Negative ! rowspan="5" style="padding:0;"| ! Total |- ! User | style="text-align:right" | '''45''' | style="text-align:right" | 5 | style="text-align:right" | 50 |- ! Non-user | style="text-align:right" | 47 | style="text-align:right" | 903 | style="text-align:right" | 950 |- | colspan="5" style="padding:0;"| |- ! Total | style="text-align:right" | '''92''' | style="text-align:right" | 908 | style="text-align:right" | 1000 |- | colspan="5" style="padding:0 0 1ex 0;border:none;background:transparent;"| 90% sensitive, 95% specific, PPV=45/92 ≈ 49% |}
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